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文件

C2150000

胆钙化醇

Name: 胆钙化醇
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

(+)-维生素 D₃, 活化7-脱氢胆固醇, 活化7-脱氢胆甾醇, 胆骨化醇

经验公式（希尔记法）:

C₂₇H₄₄O

CAS号:

67-97-0

分子量:

384.64

Beilstein:

2339331

MDL编号:

MFCD00078131

PubChem化学物质编号:

329774967

NACRES:

NA.24

生物来源

synthetic

等级

pharmaceutical primary standard

Agency

API类

cholecalciferol

形式

solid

制造商/商品名称

EDQM

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

83-86 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

−20°C

SMILES字符串

CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

InChI key

QYSXJUFSXHHAJI-YRZJJWOYSA-N

基因信息

human ... VDR(7421)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Cholecalciferol, also referred to as vitamin D₃, promotes the absorption of calcium and phosphorus in the body to regulate bone growth. It is most commonly found in humans and animals and is produced in our skin when exposed to sunlight. It is used to treat and prevent bone disorders (such as rickets, osteomalacia).

应用

Cholecalciferol for system suitability may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

生化/生理作用

维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

警示用语：

Danger

危险声明

H300 + H310 + H330 - H372

预防措施声明

P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314

危险分类

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Cholecalciferol

European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare

European pharmacopoeia, 246(6), 2058-2059 (2013)

Vitamin D is not directly necessary for bone growth and mineralization

Underwood JL and DeLuca HF

American Journal of Physiology. Endocrinology and Metabolism, 246(6), E493-E498 (1984)

Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial

Trivedi DP, et al.

BMJ (Clinical Research ed.), 326(7387), 469-469 (2003)

MART-10, a novel vitamin D analog, inhibits head and neck squamous carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and downregulation of telomerase.

Kun-Chun Chiang et al.

The Journal of steroid biochemistry and molecular biology, 138, 427-434 (2013-09-21)

For the head and neck squamous cell carcinoma (HNSCC), surgery in combination with radiation therapy is the current standard treatment. However, the complex anatomy and important functions over the head and neck region often make HNSCC patients with severe comorbidities.

Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration.

Cameron C Grant et al.

Pediatrics, 133(1), e143-e153 (2013-12-18)

To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration ≥ 20 ng/mL during infancy. A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks' gestation to birth, and then their infants, from

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