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Merck
CN

C5149

钙离子载体A23187 混合钙镁盐

Approximate 1:1 molar ratio Ca:Mg. Actual content given on label.

别名:

Calcimycin, Calcium Ionophore mixed calcium magnesium salt

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关于此项目

经验公式（希尔记法）:
C29H37N3O6
分子量:
523.62
NACRES:
NA.47
PubChem Substance ID:
24892759
UNSPSC Code:
12171500
MDL number:
MFCD00213962

主要文件

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产品名称

钙离子载体A23187 混合钙镁盐, Approximate 1:1 molar ratio Ca:Mg. Actual content given on label.

InChI

1S/C29H37N3O6.Ca.Mg/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;;/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);;/q;2*+2

SMILES string

[Mg++].[Ca++].CNc1ccc2oc(CC3OC4(CCC3C)OC(C(C)CC4C)C(C)C(=O)c5ccc[nH]5)nc2c1C(O)=O

InChI key

HKVXGTQLKZNXPV-UHFFFAOYSA-N

assay

99% (TLC)

form

powder

solubility

chloroform/methanol: 10 mg/mL, clear, faintly yellow

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

Quality Level

200

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Application

Calcium Ionophore A23187 mixed calcium magnesium salt has been used as a calcium ionophore to increase the intracellular levels of calcium.
Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not to quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000164100
0000160257
0000164100
14160914

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Method of transfection affects the cAMP-mediated induction of the RIIbeta subunit of protein kinase A in Sertoli cells: inhibition of response by increase in intracellullar calcium.
Gronning LM, et al.
European Journal of Endocrinology, 141, 75-82 (1999)
Stability of the acrosome of the brush-tailed possum (Trichosurus vulpecula) and tammar wallaby (Macropus eugenii) in vitro and after exposure to conditions and agents known to cause capacitation or acrosome reaction of eutherian spermatozoa.
Mate KE and Rodger JC
Journal of Reproduction and Fertility, 91, 41-48 (1991)
Fatima El-Assaad et al.
PLoS pathogens, 10(3), e1003839-e1003839 (2014-03-22)
In patients with cerebral malaria (CM), higher levels of cell-specific microparticles (MP) correlate with the presence of neurological symptoms. MP are submicron plasma membrane-derived vesicles that express antigens of their cell of origin and phosphatidylserine (PS) on their surface, facilitating
Reiya Taniguchi et al.
Nature communications, 6, 8545-8545 (2015-10-16)
In vertebrates, the iron exporter ferroportin releases Fe(2+) from cells into plasma, thereby maintaining iron homeostasis. The transport activity of ferroportin is suppressed by the peptide hormone hepcidin, which exhibits upregulated expression in chronic inflammation, causing iron-restrictive anaemia. However, due
Arthur Liesz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 583-598 (2015-01-16)
Acute brain lesions induce profound alterations of the peripheral immune response comprising the opposing phenomena of early immune activation and subsequent immunosuppression. The mechanisms underlying this brain-immune signaling are largely unknown. We used animal models for experimental brain ischemia as
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Data Sheet - C5149

Instructions

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