D007
R(-)-氯乙基降阿朴吗啡 盐酸盐
analytical standard
别名:
NCA 盐酸盐
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关于此项目
经验公式（希尔记法）:
C18H18ClNO2 · HCl
化学文摘社编号:
分子量:
352.25
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
方案
≥85%
表单
solid
储存条件
desiccated
protect from light
技术
HPLC: suitable
gas chromatography (GC): suitable
颜色
off-white
溶解性
0.1 M HCl: soluble
H2O: soluble
aqueous base: unstable
包装形式
neat
储存温度
2-8°C
SMILES字符串
Cl.Oc1ccc2C[C@H]3N(CCCl)CCc4cccc(c34)-c2c1O
InChI
1S/C18H18ClNO2.ClH/c19-7-9-20-8-6-11-2-1-3-13-16(11)14(20)10-12-4-5-15(21)18(22)17(12)13;/h1-5,14,21-22H,6-10H2;1H/t14-;/m1./s1
InChI key
ASPGECRWCJCPPO-PFEQFJNWSA-N
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
不可逆的多巴胺受体烷化剂
制备说明
溶于含有 0.1% 焦亚硫酸钠或者其他抗氧化剂的无氧开水中。溶液应当新制备。
警示用语：
Warning
危险声明
危险分类
STOT SE 3
靶器官
Central nervous system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
G J Kilpatrick et al.
European journal of pharmacology, 107(1), 71-78 (1984-12-15)
N-(chloroethyl)-norapomorphine (NCA) irreversibly inhibits striatal dopamine function, the binding of dopamine agonist ligands and dopamine-stimulated adenylate cyclase. A selective interaction of [3H]NCA with dopamine receptor sites would be of use in the characterisation and isolation of brain dopamine receptors. In
J Lehmann et al.
European journal of pharmacology, 90(4), 393-400 (1983-06-17)
(-)-N-(2-Chloroethyl)-norapomorphine [-)-NCA) inhibited in a concentration-dependent manner the electrically evoked [3H]acetylcholine release in slices of cat caudate. The inhibition by (-)-NCA was reversible and antagonized by the benzamide neuroleptic S-sulpiride. Although (-)-NCA is an irreversible antagonist at some behaviorally relevant
M Schmidt et al.
European journal of pharmacology, 97(1-2), 75-85 (1984-01-13)
The renal vascular effects of aporphines and related compounds were studied on the isolated perfused rat kidney in the presence of 10(-5) M phenoxybenzamine and 10(-5) M sotalol and after contraction of the vascular bed with prostaglandin F2 alpha (10(-7)
The effects of (-)N-(chloroethyl)-norapomorphine on [3H]-apomorphine binding to striatal dopamine receptors.
M W Goosey et al.
Biochemical pharmacology, 31(22), 3693-3694 (1982-11-15)
M Williams et al.
European journal of pharmacology, 91(2-3), 235-238 (1983-07-22)
NCA, the chloro analog of the potent dopamine agonist NPA is an irreversible ligand at dopamine receptors in mammalian brain. The chloroethyl analog of the recently described putative dopamine autoreceptor agonist 3-PPP, 3-PPP-C1, was evaluated for its potential use as
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