D007
R(-)-氯乙基降阿朴吗啡 盐酸盐
analytical standard
别名:
NCA 盐酸盐
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H18ClNO2 · HCl
化学文摘社编号:
分子量:
352.25
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
storage condition
protect from light, desiccated
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
InChI
1S/C18H18ClNO2.ClH/c19-7-9-20-8-6-11-2-1-3-13-16(11)14(20)10-12-4-5-15(21)18(22)17(12)13;/h1-5,14,21-22H,6-10H2;1H/t14-;/m1./s1
SMILES string
Cl.Oc1ccc2C[C@H]3N(CCCl)CCc4cccc(c34)-c2c1O
InChI key
ASPGECRWCJCPPO-PFEQFJNWSA-N
grade
analytical standard
assay
≥85%
form
solid
color
off-white
solubility
0.1 M HCl: soluble, H2O: soluble, aqueous base: unstable
format
neat
storage temp.
2-8°C
Quality Level
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
不可逆的多巴胺受体烷化剂
Preparation Note
溶于含有 0.1% 焦亚硫酸钠或者其他抗氧化剂的无氧开水中。溶液应当新制备。
signalword
Warning
hcodes
Hazard Classifications
STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
G J Kilpatrick et al.
European journal of pharmacology, 107(1), 71-78 (1984-12-15)
N-(chloroethyl)-norapomorphine (NCA) irreversibly inhibits striatal dopamine function, the binding of dopamine agonist ligands and dopamine-stimulated adenylate cyclase. A selective interaction of [3H]NCA with dopamine receptor sites would be of use in the characterisation and isolation of brain dopamine receptors. In
J Lehmann et al.
European journal of pharmacology, 90(4), 393-400 (1983-06-17)
(-)-N-(2-Chloroethyl)-norapomorphine [-)-NCA) inhibited in a concentration-dependent manner the electrically evoked [3H]acetylcholine release in slices of cat caudate. The inhibition by (-)-NCA was reversible and antagonized by the benzamide neuroleptic S-sulpiride. Although (-)-NCA is an irreversible antagonist at some behaviorally relevant
Dopamine autoreceptors differ pharmacologically from postsynaptic dopamine receptors: effects of (-)-N-(2-chloroethyl)-norapomorphine.
J Lehmann et al.
European journal of pharmacology, 77(1), 85-86 (1982-01-08)
S A Cohen et al.
Journal of medicinal chemistry, 26(10), 1348-1353 (1983-10-01)
The rates and mechanism of solvolysis of (-)-N-(2-chloroethyl)norapomorphine (NCA, 1c) in aqueous solution have been examined by reversed-phase liquid chromatography (HPLC) to follow the levels of starting material and products. The first-order rate constants for aziridinium ion formation at 25
J H Guan et al.
Journal of medicinal chemistry, 27(6), 806-810 (1984-06-01)
The synthesis of the title compounds (1c and its 2H isomer 1b) from N-(2-hydroxyethyl)norapomorphine was carried out by ring bromination, followed by chlorination to the 2-chloroethyl compound 6. Further reduction with 2H2 or 3H2 and Pd/C gave 1b or 1c.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持