IA00008
DOTAP 氯化物
别名:
N- [1-（2，3-二油酰氧基）丙基] -N，N，N-三甲基氯化铵
InChI key
KSXTUUUQYQYKCR-LQDDAWAPSA-M
InChI
1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;
SMILES string
[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]
biological source
synthetic
assay
≥99% (HPLC)
form
solid
packaging
pkg of 1 × 200 mg (IA00008-200MG)
color
white to off-white
lipid type
cationic lipids
shipped in
dry ice
storage temp.
−20°C
Quality Level
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General description
DOTAP chloride in research is as a transfection reagent for the delivery of nucleic acids, such as DNA and RNA, into cells. DOTAP chloride, also known as 1,2-dioleoyl-3-trimethylammonium-propane chloride, is a cationic lipid that is often used to form liposomal complexes with nucleic acids, enabling their efficient delivery into cells. This makes it a valuable tool in molecular biology, gene expression studies, and the development of gene therapy techniques.
Application
由阳离子脂质体组成的化合物，用于向真核细胞中转染DNA、RNA及其他负电性分子。DNA与DOTAP混合时会自动形成稳定的复合物，后者可直接加入细胞培养基中。这些复合物能够与细胞膜融合并向细胞质中释放DNA。细胞被高效转染的同时不会产生细胞毒性。每μg DNA需使用5-10 μg左右的DOTAP，每mL 细胞培养基需加入约10-20 μg DOTAP。最佳的工作浓度和转染试剂视被转染的细胞系，以及转染试材类型（RNA、DNA、蛋白）而定。
Advanced drug delivery
Features and Benefits
Research grade products that can easily be scaled to meets GMP needs.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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