M3157
米那卜林 二盐酸盐
analytical standard
别名:
N-(4-甲基-6-苯基-3-哒嗪基)-4-吗啉乙胺
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关于此项目
经验公式（希尔记法）:
C17H22N4O · 2HCl
化学文摘社编号:
分子量:
371.30
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
247-329-8
MDL number:
InChI key
GNUCGROXDZMCJI-UHFFFAOYSA-N
InChI
1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H
SMILES string
Cl.Cl.Cc1cc(nnc1NCCN2CCOCC2)-c3ccccc3
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Gene Information
human ... ACHE(43), CHRM1(1128), DRD2(1813), HTR2B(3357), HTR2C(3358), MAOA(4128), SLC6A4(6532)
rat ... Ache(83817), Camk2a(25400), Prkca(24680)
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
抗抑郁剂
R G Priest et al.
Journal of clinical psychopharmacology, 16(6), 420-424 (1996-12-01)
A very large number of therapeutic trials of antidepressant drugs have been reported in the scientific literature. Until now, the comparison of one drug with another, or with placebo, has been performed typically by comparing the scores on depression rating
Y Piao et al.
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 15(2), 157-163 (1995-04-01)
This study examines the effect of the psychotropic drug minaprine on memory impairment in Mongolian gerbils subjected to a 5-min bilateral common carotid artery occlusion, as assessed by their performance in an 8-arm radial maze task. Gerbils were initially trained
[Three cases of acute agranulocytosis: caused by minaprine?].
Y Bastion et al.
Presse medicale (Paris, France : 1983), 22(2), 82-83 (1993-01-23)
D Wheatley
The British journal of psychiatry : the journal of mental science, 161, 113-115 (1992-07-01)
Minaprine (200 mg daily, either once or divided b.d.) was compared with amitriptyline (25-50 mg t.d.s.) over six weeks in 144 patients with major depression. Significant reductions in HRSD scores at the end of six weeks' treatment were recorded with
S Chaki et al.
Neurochemistry international, 24(1), 37-41 (1994-01-01)
Involvement of protein kinase C (PKC) activation in the regulation of acetylcholine (ACh) release from rat hippocampal slices by minaprine, [3(2-morpholinoethylamino)-4-methyl-6-phenylpyridazine] was investigated. Phorbol esters such as 4 beta-phorbol 12,13-dibutylate (PDBu) and 12-o-tetradecanoylphorbol 13-acetate (TPA) enhanced high K(+)-evoked [3H]ACh release
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