M3157
米那卜林 二盐酸盐
analytical standard
别名:
N-(4-甲基-6-苯基-3-哒嗪基)-4-吗啉乙胺
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关于此项目
经验公式（希尔记法）:
C17H22N4O · 2HCl
化学文摘社编号:
分子量:
371.30
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
Cl.Cl.Cc1cc(nnc1NCCN2CCOCC2)-c3ccccc3
InChI
1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H
InChI key
GNUCGROXDZMCJI-UHFFFAOYSA-N
基因信息
human ... ACHE(43), CHRM1(1128), DRD2(1813), HTR2B(3357), HTR2C(3358), MAOA(4128), SLC6A4(6532)
rat ... Ache(83817), Camk2a(25400), Prkca(24680)
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
抗抑郁剂
D Wheatley
The British journal of psychiatry : the journal of mental science, 161, 113-115 (1992-07-01)
Minaprine (200 mg daily, either once or divided b.d.) was compared with amitriptyline (25-50 mg t.d.s.) over six weeks in 144 patients with major depression. Significant reductions in HRSD scores at the end of six weeks' treatment were recorded with
[Three cases of acute agranulocytosis: caused by minaprine?].
Y Bastion et al.
Presse medicale (Paris, France : 1983), 22(2), 82-83 (1993-01-23)
Antidepressant response follows an exponential decay curve: replication and extension.
W Boyer
Journal of clinical psychopharmacology, 17(5), 426-427 (1997-10-08)
S Chaki et al.
Neurochemistry international, 24(1), 37-41 (1994-01-01)
Involvement of protein kinase C (PKC) activation in the regulation of acetylcholine (ACh) release from rat hippocampal slices by minaprine, [3(2-morpholinoethylamino)-4-methyl-6-phenylpyridazine] was investigated. Phorbol esters such as 4 beta-phorbol 12,13-dibutylate (PDBu) and 12-o-tetradecanoylphorbol 13-acetate (TPA) enhanced high K(+)-evoked [3H]ACh release
J G Edwards et al.
British journal of clinical pharmacology, 42(4), 491-498 (1996-10-01)
1. A double-blind, multicentre study comparing the efficacy and safety of minaprine and amitriptyline in patients with major depression was carried out. Five hundred and thirty-one patients were randomly assigned to treatment with either minaprine 100 mg, 200 mg or
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