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Merck
CN

P8721

青霉素G 钾盐

别名:

苄青霉素 钾盐

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关于此项目

经验公式(希尔记法):
C16H17KN2O4S
化学文摘社编号:
分子量:
372.48
Beilstein:
3832841
EC 号:
MDL编号:
UNSPSC代码:
51283405
eCl@ss:
34010400
PubChem化学物质编号:
NACRES:
NA.21
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表单

crystalline powder

质量水平

效能

1440-1680 units per mg

抗生素抗菌谱

Gram-positive bacteria

应用

pharmaceutical (small molecule)

作用机制

cell wall synthesis | interferes

SMILES字符串

[K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O

InChI

1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChI key

IYNDLOXRXUOGIU-LQDWTQKMSA-M

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一般描述

Chemical structure: ß-lactam

应用

Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.

生化/生理作用

作用机制:青霉素G通过与青霉素结合蛋白(PBP)结合抑制肽聚糖链交联,从而抑制细胞壁合成。

抗菌谱:本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。

包装

10mu,25mu,100mu

其他说明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

免责声明

溶液应过滤杀菌,在 2-8°C 下最长可储存一周,在 -20°C 下可长期储存。溶液在 37°C 下可稳定 3 天。

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Lemierre's syndrome in systemic lupus erythematosus: a report of two cases.
J C Rødgaard et al.
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Mariagrazia Perilli et al.
Antimicrobial agents and chemotherapy, 57(2), 1047-1049 (2012-11-28)
Two laboratory mutant forms, TEM-149(H240) and TEM-149(H164-H240), of the TEM-149 extended-spectrum β-lactamase enzyme were constructed by site-directed mutagenesis. TEM-149(H240) and TEM-149(H164-H240) were similar in kinetic behavior, except with respect to benzylpenicillin and ceftazidime. Molecular modeling of the two mutant enzymes
Eleonor G Lago et al.
Sexually transmitted diseases, 40(2), 85-94 (2013-01-18)
The aim of this study was to investigate clinical features and outcomes of children treated for congenital syphilis (CS). Infants born alive in the public sector of São Lucas Hospital, Porto Alegre, Brazil, 1997 to 2004, whose mothers had syphilis
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Antifolates, in particular methotrexate (MTX), have been widely used in the treatment of primary and secondary tumors of the central nervous system (CNS). Pemetrexed (PMX) is a novel antifolate that also exhibits potent antitumor activity against CNS malignancies. Studies have
Vasim Ahmed et al.
Journal of biotechnology, 163(4), 419-424 (2013-01-12)
In the present study, a novel strategy was adopted to synthesize, β lactamase resistant penicillin G molecules by using the unique properties of silver nanoparticles. Ascorbic acid-stabilized spherical monodispersed silver nanoparticles were prepared by a simple chemical reaction. The formation

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