P8721
青霉素G 钾盐
别名:
苄青霉素 钾盐
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关于此项目
经验公式（希尔记法）:
C16H17KN2O4S
化学文摘社编号:
分子量:
372.48
NACRES:
NA.21
PubChem Substance ID:
eCl@ss:
34010400
UNSPSC Code:
51283405
EC Number:
204-038-0
MDL number:
Beilstein/REAXYS Number:
3832841
InChI key
IYNDLOXRXUOGIU-LQDWTQKMSA-M
InChI
1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
SMILES string
[K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O
form
crystalline powder
potency
1440-1680 units per mg
antibiotic activity spectrum
Gram-positive bacteria
application(s)
pharmaceutical (small molecule)
mode of action
cell wall synthesis | interferes
Quality Level
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Biochem/physiol Actions
作用机制：青霉素G通过与青霉素结合蛋白(PBP)结合抑制肽聚糖链交联，从而抑制细胞壁合成。
抗菌谱：本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。
抗菌谱：本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。
Disclaimer
溶液应过滤杀菌，在 2-8°C 下最长可储存一周，在 -20°C 下可长期储存。溶液在 37°C 下可稳定 3 天。
Application
Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place
Packaging
10mu,25mu,100mu
General description
Chemical structure: β-lactam
signalword
Warning
hcodes
pcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
涉药品监管产品
此项目有
Tina Lund Leunbach et al.
Ugeskrift for laeger, 175(11), 742-743 (2013-03-14)
A pregnant Caucasian woman with newly diagnosed syphilis in the secondary stage was hospitalized for observation while being treated with penicillin. After one dose of penicillin the foetus was delivered by a caesarean section at gestational age 28 weeks +
Muneki Hotomi et al.
PloS one, 8(3), e58124-e58124 (2013-03-14)
The protection against pneumococcal infections provided by currently available pneumococcal polysaccharide conjugate vaccines are restricted to the limited number of the serotypes included in the vaccine. In the present study, we evaluated the distribution of the pneumococcal capsular type and
Vasim Ahmed et al.
Journal of biotechnology, 163(4), 419-424 (2013-01-12)
In the present study, a novel strategy was adopted to synthesize, β lactamase resistant penicillin G molecules by using the unique properties of silver nanoparticles. Ascorbic acid-stabilized spherical monodispersed silver nanoparticles were prepared by a simple chemical reaction. The formation
R Vacheva et al.
Akusherstvo i ginekologiia, 51(6), 10-21 (2013-02-09)
The results achieved with 80% reduction in the incidence of early-onset neonatal group B streptococcal (GBS) sepsis following the implementation of the preliminary (1996, 2002) and subsequently the revised (2010) guidelines for intrapartum antibiotic prophylaxis imposed the discussion on a
Lemierre's syndrome in systemic lupus erythematosus: a report of two cases.
J C Rødgaard et al.
Scandinavian journal of rheumatology, 42(2), 167-168 (2013-01-15)
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