PHR1089
西咪替丁 盐酸盐
Pharmaceutical Secondary Standard; Certified Reference Material
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关于此项目
经验公式（希尔记法）:
C10H16N6S · HCl
化学文摘社编号:
分子量:
288.80
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
274-297-2
Beilstein/REAXYS Number:
5668216
MDL number:
InChI key
QJHCNBWLPSXHBL-UHFFFAOYSA-N
InChI
1S/C10H16N6S.ClH/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11;/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);1H
SMILES string
Cl.CN\C(NC#N)=N/CCSCc1nc[nH]c1C
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. C2175500, traceable to USP 1134073
API family
cimetidine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... HRH2(3274)
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General description
Cimetidine is a histamine H2-receptor antagonist, widely used to inhibit gastric acid secretion. It finds application in the treatment of gastric and duodenal ulcers.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Cimetidine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical preparations using gas chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7168 in the slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
GC Determination of famotidine, ranitidine, cimetidine, and metformin in pharmaceutical preparations and serum using methylglyoxal as derivatizing reagent
Majidano AS, et al.
Chromatographia, 75(21-22), 1311-1317 (2012)
Yisheng Zheng et al.
Molecular immunology, 54(1), 74-83 (2012-12-12)
Cimetidine, a histamine type-2 receptor antagonist, is known to inhibit the growth of several tumors in human and animals, however the mechanism of action underlying this effect remains largely unknown. Here, in the mice model of 3LL lung tumor, cimetidine
Toru Arino et al.
European journal of pharmacology, 693(1-3), 72-79 (2012-09-13)
The antiprotozoal agent pentamidine, used for the treatment of Pneumocystis jirovecii pneumonia (PCP), is known to cause abnormalities in blood glucose homeostasis, such as hypoglycemia and hyperglycemia. Pentamidine has been reported to be a substrate of organic cation transporter 1
Christine Brauckmann et al.
Journal of chromatography. A, 1279, 49-57 (2013-01-29)
Cimetidine has been studied as an additive in cancer chemotherapy. It is claimed to reduce the side effects of Cisplatin. This study focuses on possible interactions between Cisplatin and cimetidine on the molecular level. Due to the fact that cimetidine
Renata Longhini et al.
Journal of anatomy, 222(2), 239-247 (2012-12-04)
It has been demonstrated that histamine interferes with the recruitment, formation and activity of osteoclasts via H(1)- and H(2)-receptors. Cimetidine is a H(2)-receptor antagonist used for treatment of gastric ulcers that seems to prevent bone resorption. In this study, a
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