PHR1154
柠檬酸三丁酯
Pharmaceutical Secondary Standard; Certified Reference Material
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关于此项目
经验公式（希尔记法）:
C18H32O7
化学文摘社编号:
分子量:
360.44
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
201-071-2
Beilstein/REAXYS Number:
1806072
MDL number:
InChI key
ZFOZVQLOBQUTQQ-UHFFFAOYSA-N
InChI
1S/C18H32O7/c1-4-7-10-23-15(19)13-18(22,17(21)25-12-9-6-3)14-16(20)24-11-8-5-2/h22H,4-14H2,1-3H3
SMILES string
CCCCOC(=O)CC(O)(CC(=O)OCCCC)C(=O)OCCCC
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to USP 1680608
API family
tributyl acetylcitrate
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
refractive index
n20/D 1.445
density
1.043 g/mL at 20 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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General description
Tributyl citrate is an ester of citric acid. It is used to plasticize polymers for coating solid drug dosage forms, tablets and capsules.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8989 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Handbook of Pharmaceutical Excipients, 1 (2006)
D Hutchings et al.
Pharmaceutical research, 11(10), 1474-1478 (1994-10-01)
The influence of curing time and curing temperature for a commercially available ethylcellulose latex coating dispersion (Aquacoat) were evaluated using response surface methodology. Levels for the factor curing time ranged from 30 to 300 minutes while levels for curing temperature
P Eickholz et al.
Journal of periodontology, 71(6), 999-1008 (2000-07-29)
The aim of this study was to compare the effects of guided tissue regeneration (GTR) using 2 different bioabsorbable barriers (control: polylactide acetyltributyl citrate; test: polydioxanon). The polydioxanon barrier is an experimental membrane for GTR therapy that consists of a
Bernadette Pretzl et al.
Journal of clinical periodontology, 36(4), 349-356 (2009-05-12)
Evaluation of the 10-year results after GTR-therapy of infrabony defects using two bioabsorbable barriers in a randomized-controlled clinical trial. In 15 patients with periodontitis, 15 pairs of infrabony defects were treated. For each patient, one defect received a polydioxanon (test:
Eva Roblegg et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 79(3), 635-645 (2011-08-02)
The objective of this study was the development of retarded release pellets using vegetable calcium stearate (CaSt) as a thermoplastic excipient. The matrix carrier was hot melt extruded and pelletized with a hot-strand cutter in a one step continuous process.
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