Merck
CN

PHR1284

Supelco

氯磺丙脲

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
对氯苯磺酰丙脲
经验公式(希尔记法):
C10H13ClN2O3S
CAS号:
分子量:
276.74
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to Ph. Eur. C1905000
traceable to USP 1126009

API类

chlorpropamide

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1

InChI

1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)

InChI key

RKWGIWYCVPQPMF-UHFFFAOYSA-N

基因信息

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Chlorpropamide belongs to the sulfonylurea class of drugs and is found to be clinically effective in the treatment of Diabetes mellitus (DM). Its mode of action involves the stimulation of insulin release from the β-cells of the pancreas in response to a glucose load. It helps in increasing the number of insulin receptors, thereby enhancing the effect of insulin on the liver and promotes peripheral glucose utilization.

应用

Chlorpropamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using capillary zone elctrophoresis technique and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA0019 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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A capillary zone electrophoretic method for the determination of hypoglycemics as adulterants in herbal formulations used for the treatment of diabetes
Viana C, et al.
Analytical Methods : Advancing Methods and Applications, 5(8), 2126-2133 (2013)
Spectrophotometric Determination of Chlorpropamide in Bulk and Dosage Form by Complexation with Chloranilic Acid
Mbah JC and Okorie HN
Journal of Scientific Research, 3(1), 2126-2133 (2011)
Qing Zhu et al.
Molecular pharmaceutics, 7(4), 1291-1300 (2010-06-17)
As a result of an increase in the number of emerging therapies with dissolution limited bioavailability, formulation strategies such as solid dispersions that enhance the rate of solubilization are of interest. In this study, the microstructure of solid dispersions prepared
Duangporn Wanapun et al.
Analytical chemistry, 82(13), 5425-5432 (2010-06-03)
Second order nonlinear optical imaging of chiral crystals (SONICC) was applied to selectively detect crystal formation at early stages and characterize the kinetics of nucleation and growth. SONICC relies on second harmonic generation (SHG), a nonlinear optical effect that only
Yury V Seryotkin et al.
Acta crystallographica. Section B, Structural science, 69(Pt 1), 77-85 (2013-02-01)
The crystal structure of the high-pressure polymorph (α') of an antidiabetic drug, chlorpropamide [4-chloro-N-(propylaminocarbonyl)benzenesulfonamide, C(10)H(13)ClN(2)O(3)S], which is formed at ~2.8 GPa from the α-polymorph (P2(1)2(1)2(1)) on hydrostatic compression in saturated ethanol solution, has been determined. As a result of the

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