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Merck
CN

PHR1284

氯磺丙脲

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

对氯苯磺酰丙脲

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经验公式(希尔记法):
C10H13ClN2O3S
化学文摘社编号:
分子量:
276.74
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
202-314-5
MDL number:
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InChI key

RKWGIWYCVPQPMF-UHFFFAOYSA-N

InChI

1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)

SMILES string

CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C1905000, traceable to USP 1126009

API family

chlorpropamide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

Gene Information

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Chlorpropamide belongs to the sulfonylurea class of drugs and is found to be clinically effective in the treatment of Diabetes mellitus (DM). Its mode of action involves the stimulation of insulin release from the β-cells of the pancreas in response to a glucose load. It helps in increasing the number of insulin receptors, thereby enhancing the effect of insulin on the liver and promotes peripheral glucose utilization.

Application

Chlorpropamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using capillary zone elctrophoresis technique and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0019 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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A capillary zone electrophoretic method for the determination of hypoglycemics as adulterants in herbal formulations used for the treatment of diabetes
Viana C, et al.
Analytical Methods : Advancing Methods and Applications, 5(8), 2126-2133 (2013)
Qing Zhu et al.
Molecular pharmaceutics, 7(4), 1291-1300 (2010-06-17)
As a result of an increase in the number of emerging therapies with dissolution limited bioavailability, formulation strategies such as solid dispersions that enhance the rate of solubilization are of interest. In this study, the microstructure of solid dispersions prepared
Yury V Seryotkin et al.
Acta crystallographica. Section B, Structural science, 69(Pt 1), 77-85 (2013-02-01)
The crystal structure of the high-pressure polymorph (α') of an antidiabetic drug, chlorpropamide [4-chloro-N-(propylaminocarbonyl)benzenesulfonamide, C(10)H(13)ClN(2)O(3)S], which is formed at ~2.8 GPa from the α-polymorph (P2(1)2(1)2(1)) on hydrostatic compression in saturated ethanol solution, has been determined. As a result of the
Jer-Yen Yang et al.
Cancer research, 70(11), 4709-4718 (2010-05-21)
Drug resistance is a central challenge of cancer therapy that ultimately leads to treatment failure. In this study, we characterized a mechanism of drug resistance that arises to AZD6244, an established mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitor currently
Spectrophotometric Determination of Chlorpropamide in Bulk and Dosage Form by Complexation with Chloranilic Acid
Mbah JC and Okorie HN
Journal of Scientific Research, 3(1), 2126-2133 (2011)

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