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PHR1625

卢非酰胺

Name: 卢非酰胺
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Rufinamide, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide

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关于此项目

经验公式（希尔记法）:

C₁₀H₈F₂N₄O

化学文摘社编号:

106308-44-5

分子量:

238.19

NACRES:

NA.24

PubChem Substance ID:

329823517

UNSPSC Code:

41116107

MDL number:

MFCD00865314

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1606401

API family

rufinamide

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

NC(=O)c1cn(Cc2c(F)cccc2F)nn1

InChI

1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)

InChI key

POGQSBRIGCQNEG-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

说明

General description

Rufinamide is an antiepileptic drug, used as an adjunctive for the treatment of seizures associated with Lennox−Gastaut syndrome. Its mode of action involves prolonging the refractory period of voltage-dependent sodium channels via stabilization of the sodium channel inactive state, thus effectively keeping the ion channels closed.

Effective therapy for partial seizures in adults and childhood seizures in Lennox-Gastaut syndrome.

Application

Rufinamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Broad-spectrum anticonvulsant.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA5294 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H336,H351,H361fd

pcodes

P202 - P261 - P271 - P280 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Carc. 2 - Repr. 2 - STOT SE 3

target_organs

Central nervous system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c