PHR1629
托灭酸
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
托芬那酸, 2-(3-氯-2-甲基苯胺)苯甲酸, 2-([3-氯-2-甲苯基]氨基)苯甲酸
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关于此项目
经验公式（希尔记法）:
C14H12ClNO2
化学文摘社编号:
分子量:
261.70
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
237-264-3
MDL number:
InChI
1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
InChI key
YEZNLOUZAIOMLT-UHFFFAOYSA-N
SMILES string
Cc1c(Cl)cccc1Nc2ccccc2C(O)=O
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0000154
API family
tolfenamic acid
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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General description
Tolfenamic Acid is an anthranilic acid derivative and a non-steroidal anti-inflammatory drug (NSAID). Its applications in treating pancreatic, esophageal, colorectal and lung cancer is being investigated.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tolfenamic Acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using anionic capillary isotachophoresis (ITP) technique.
Biochem/physiol Actions
Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA5493 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Small Animal Clinical Pharmacology, 23(1), 135-142 (2008)
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, 23(16), 135-142 (2015)
Capillary isotachophoretic determination of flufenamic, mefenamic, niflumic and tolfenamic acid in pharmaceuticals
Polasek M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 23(1), 135-142 (2000)
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