S9251
对氨基苯磺酰胺
≥98%
别名:
对氨基苯磺酰胺
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关于此项目
线性分子式:
H2NC6H4SO2NH2
化学文摘社编号:
分子量:
172.20
NACRES:
NA.76
PubChem Substance ID:
eCl@ss:
39093202
UNSPSC Code:
51283932
EC Number:
200-563-4
MDL number:
Beilstein/REAXYS Number:
511852
产品名称
对氨基苯磺酰胺, ≥98%
InChI
1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
SMILES string
Nc1ccc(cc1)S(N)(=O)=O
InChI key
FDDDEECHVMSUSB-UHFFFAOYSA-N
assay
≥98%
form
powder or crystals
color
white to off-white
mp
164-166 °C (lit.)
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
DNA synthesis | interferes
enzyme | inhibits
Quality Level
Gene Information
human ... CA1(759), CA2(760), CA5A(763), CA5B(11238), CA9(768)
mouse ... Car13(71934), Car5a(12352)
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Biochem/physiol Actions
磺胺类抗生素通过抑制酶二氢蝶酸合成酶能够阻止二氢叶酸合成。
作用模型：一种二氢蝶酸合成酶竞争性抑制剂阻止二氢叶酸合成。
抗微生物谱：革兰氏阳性，革兰氏阴性，衣原体病
抗性模型：二氢蝶酸合成酶取代或二氢叶酸合成取代途径。
作用模型：一种二氢蝶酸合成酶竞争性抑制剂阻止二氢叶酸合成。
抗微生物谱：革兰氏阳性，革兰氏阴性，衣原体病
抗性模型：二氢蝶酸合成酶取代或二氢叶酸合成取代途径。
General description
化学结构：磺胺
Other Notes
保持容器密闭，置于干燥通风处。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
I Meneau et al.
Antimicrobial agents and chemotherapy, 48(7), 2610-2616 (2004-06-25)
Failure of anti-Pneumocystis jiroveci prophylaxis with sulfa drugs is associated with mutations within the putative active site of the fungal dihydropteroate synthase (DHPS), an enzyme encoded by the multidomain FAS gene. This enzyme is involved in the essential biosynthesis of
Rajwinder Singh et al.
Biomedical optics express, 11(7), 3733-3752 (2020-10-06)
In pregnancy during an inflammatory condition, macrophages present at the feto-maternal junction release an increased amount of nitric oxide (NO) and pro-inflammatory cytokines such as TNF-α and INF-γ, which can disturb the trophoblast functions and pregnancy outcome. Measurement of the
Edward E Knaus et al.
Bioorganic & medicinal chemistry letters, 21(19), 5892-5896 (2011-08-20)
A series of compounds incorporating regioisomeric phenylethynylbenzenesulfonamide moieties has been investigated for the inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, IX and XII. Inhibition between the low nanomolar to the milliomolar range has been
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 20(7), 2178-2182 (2010-03-10)
A beta-carbonic anhydrase (CA, EC 4.2.1.1) from the bacterial pathogen Brucella suis, bsCA 1, has been cloned, purified characterized kinetically and for inhibition with a series of water soluble glycosylated sulfanilamides. bsCA 1 has appreciable activity as catalyst for the
Claudia Temperini et al.
Journal of medicinal chemistry, 53(2), 850-854 (2009-12-24)
Coumarins constitute a general and totally new class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), binding at the entrance of the active site cavity. We report here that the coumarin-binding site in CAs may interact with
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