SMB01374
16α-Hydroxydehydroepiandrosterone
≥95% (HPLC)
别名:
(3β,16α)-3,16-Dihydroxyandrost-5-en-17-one, 16α-Hydroxy-DHEA, 16α-OH-DHEA, 16OH-DHEA, 16alpha-Hydroxy-DHEA, 16alpha-Hydroxydehydroepiandrosterone, 16alpha-OH-DHEA, 3,16-Dihydroxyandrost-5-en-17-one, 5-Androsten-3β,16α-diol-17-one, Androst-5-ene-3β-16α-diol-17-one
生物来源
synthetic
质量水平
方案
≥95% (HPLC)
表单
solid
储存温度
2-8°C
SMILES字符串
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@](CC3)(C(=O)[C@@H](C4)O)C)CC=C2C1)C
InChI
1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h3,12-16,20-21H,4-10H2,1-2H3/t12-,13+,14-,15-,16+,18-,19-/m0/s1
InChI key
QQIVKFZWLZJXJT-DNKQKWOHSA-N
应用
16α-Hydroxydehydroepiandrosterone (16OH-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone (DHEA). It is formed upon 16-hydroxylation by the cytochrome P450 (CYP) enzyme CYP3A4 and fetal/neonatal form CYP3A7. 16OH-DHEA is the precursor of fetal 16alpha-hydroxylated estrogens, the main phenolic steroids in pregnancy. Their serum levels are used as biochemical markers of the well being of the fetus. In adults, increased levels of 16-hydroxylated estrogens are thought to correlate with the risk of cancer and some systemic autoimmune diseases.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
监管及禁止进口产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Zhen-Biao Zhang et al.
Frontiers in pharmacology, 9, 1181-1181 (2018-11-06)
Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of
Qing-Feng Xie et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 8856135-8856135 (2021-01-12)
Curcumin (CUR) possesses pronounced anti-inflammatory and antioxidant activities. Generally, the clinical application of CUR is restricted due to its apparent unstability and poor absorption, and the biological activities of CUR may be closely associated with its metabolites. Tetrahydrocurcumin (THC) and
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