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Merck
CN

T9765

托屈嗪 盐酸盐

analytical standard

别名:

盐酸托屈嗪

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经验公式(希尔记法):
C11H12N4O2 · HCl
化学文摘社编号:
分子量:
268.70
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
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SMILES string

Cl.CCOC(=O)NNc1nncc2ccccc12

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

抗高血压药

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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K Gasiorowski et al.
Polish journal of occupational medicine and environmental health, 6(4), 383-389 (1993-01-01)
Hydralazine, dihydralazine and todralazine were tested in the aspect of their mutagenic potency, and the influence upon the mutagenicity of standard promutagen--B(a)P. Hydralazine exhibited strong mutagenic activity in the Ames test while mutagenic activity of dihydralazine was relatively weak. Todralazine
M Drózdz et al.
Clinical physiology and biochemistry, 7(2), 97-100 (1989-01-01)
Fibroblast cultures exposed to the drugs inducing a collagen-like syndrome (hydralazine and binazine) displayed growth inhibition and decrease in cellular protein content in a dose-dependent manner compared with control cultures. This was accompanied by the inhibitory effect of the drugs
K Gasiorowski et al.
International journal of occupational medicine and environmental health, 8(3), 267-273 (1995-01-01)
We have previously described that todralazine markedly decreased mutagenicity of several indirect- and direct-acting mutagens. In this paper we report the results of experiments conducted in order to evaluate the involvement of desmutagenic and bio-antimutagenic activities in the observed antimutagenic
K Olczyk et al.
Acta medica Hungarica, 45(2), 161-169 (1988-01-01)
Serum antinuclear antibodies were induced in rats by treatment with hydralazine or todralazine, given in daily dose of 25 mg/kg of body wt. for 12 months. An increased activity of alpha-glucosidase, beta-glucosidase, beta-galactosidase, alpha-fucosidase, beta-xylosidase was found in heart muscle
Z Gomez de Balugera et al.
Journal of pharmaceutical and biomedical analysis, 12(7), 883-887 (1994-07-01)
Differential pulse polarography (DPP) is proposed as a direct method for the quantitation of todralazine and acetazolamide in human serum. The method was applied to the determination of these drugs in human serum, after a liquid-liquid extraction process. This extraction

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