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文件

COO原产地证书/COA分析证书

Y0000578

帕罗西汀

Name: 帕罗西汀
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

Paroxetine hydrochloride, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride

经验公式（希尔记法）:

C₁₉H₂₀FNO₃ · HCl

CAS号:

78246-49-8

分子量:

365.83

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

paroxetine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

InChI

1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1

InChI key

GELRVIPPMNMYGS-RVXRQPKJSA-N

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Paroxetine hydrochloride (anhydrous) EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1500230

1500240

1500251

1500273

1500284

Y0000579

帕罗西汀杂质C, European Pharmacopoeia (EP) Reference Standard

PHR1804

帕罗西汀, Pharmaceutical Secondary Standard; Certified Reference Material

BP1024

帕罗西汀盐酸盐半水合物, British Pharmacopoeia (BP) Reference Standard

BP746

帕罗西汀杂质标准品, British Pharmacopoeia (BP) Reference Standard

1500207

PHR3076

PHR3077

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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索取COA

How often did Belgian physicians co-prescribe tamoxifen with strong CYP2D6 inhibitors over the last 6 years?

A S Dieudonné et al.

Acta clinica Belgica, 69(1), 47-52 (2014-03-19)

Tamoxifen is widely used in the treatment of breast cancer. It is a pro-drug metabolized to the more active endoxifen through CYP2D6. Concomitant intake of CYP2D6 inhibitors results in lower endoxifen levels and could influence efficacy. The objective of this

A little better than placebo is still better than nothing.

Adrian S Dobs

Nature medicine, 19(8), 962-962 (2013-08-08)

Pharmacokinetic properties of once-daily oral low-dose mesylate salt of paroxetine (LDMP 7.5 mg) following single and multiple doses in healthy postmenopausal women.

M Cristina Castelli et al.

Clinical therapeutics, 35(6), 862-869 (2013-06-26)

Low-dose mesylate salt of paroxetine (LDMP 7.5 mg) is being investigated for the treatment of vasomotor symptoms associated with menopause. This Phase I, open-label, single- and multiple-dose study evaluated the pharmacokinetic properties, safety and tolerability of LDMP in postmenopausal, nonsmoking

Fresh onion juice enhanced copulatory behavior in male rats with and without paroxetine-induced sexual dysfunction.

Mohammed Z Allouh et al.

Experimental biology and medicine (Maywood, N.J.), 239(2), 177-182 (2013-12-05)

Onion (Allium cepa) is one of the most commonly cultivated species of the family Liliaceae, and has long been used in dietary and therapeutic applications. Treatment with fresh onion juice has been reported to promote testosterone production in male rats.

Low-dose paroxetine 7.5 mg for menopausal vasomotor symptoms: two randomized controlled trials.

James A Simon et al.

Menopause (New York, N.Y.), 20(10), 1027-1035 (2013-09-21)

The efficacy and safety of low-dose paroxetine 7.5 mg for the treatment of menopausal vasomotor symptoms were evaluated in two multicenter, double-blind, placebo-controlled, phase 3 studies of 12 and 24 weeks' duration. Postmenopausal women were randomly assigned 1:1 to receive

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