Diisopropyl ether (DIPE) is branched ether. It is a peroxide forming solvent. This process is catalyzed by heat, light and oxygen. For such solvents small amount of stabilizers like BHT (butylated hydroxytoluene) or hydroquinone is added which removes the free radicals that form peroxides. DIPE has been proposed as a potential alternative oxygenated fuel additive. Several methods have been proposed for its synthesis using acetone as starting material. The molecular structure and conformation has been studied using gas-phase electron diffusion. Its potential carcinogenicity has been studied in Sprague-Dawley rats.

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Diisopropyl ether may be used as a solvent in the following processes:

• Resolution of secondary alcohols.
• Enantioselective acylation of 1-phenethylamine.
• Synthesis of aliphatic and aromatic cyanohydrins.