02582
4-Pyridoxolactone
≥98.5% (HPLC)
别名:
β-Pyracin, 4-Pyridoxic acid lactone, 7-Hydroxy-6-methylfuro[3,4-c]pyridin-1(3H)-one
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关于此项目
经验公式（希尔记法）:
C8H7NO3
化学文摘社编号:
分子量:
165.15
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
140752
产品名称
4-Pyridoxolactone, ≥98.5% (HPLC)
InChI
1S/C8H7NO3/c1-4-7(10)6-5(2-9-4)3-12-8(6)11/h2,10H,3H2,1H3
SMILES string
O=C1OCC2=CN=C(C)C(O)=C21
InChI key
HHPDVQLBYQFYFA-UHFFFAOYSA-N
assay
≥98.5% (HPLC)
98.5-101.5% (T)
form
powder
technique(s)
HPLC: suitable
color
white to light yellow
storage temp.
−20°C
Biochem/physiol Actions
4-Pyridoxolactone is a bacterial oxidation metabolite of vitamin B6.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Nana Yokochi et al.
The Journal of biological chemistry, 279(36), 37377-37384 (2004-07-01)
Microbacterium luteolum YK-1 has pyridoxine degradation pathway I. We have cloned the structural gene for the second step enzyme, pyridoxal 4-dehydrogenase. The gene consists of 1,026-bp nucleotides and encodes 342 amino acids. The enzyme was overexpressed under cold shock conditions
Z Bannur et al.
Clinical biochemistry, 47(6), 427-431 (2014-03-04)
Acute lymphoblastic leukaemia (ALL) has posed challenges to the clinician due to variable patients' responses and late diagnosis. With the advance in metabolomics, early detection and personalised treatment are possible. Metabolomic profile of 21 ALL patients treated with 6-mercaptopurine and
P Edwards et al.
Clinica chimica acta; international journal of clinical chemistry, 190(1-2), 67-80 (1990-09-01)
The effects of increased intake of pyridoxine hydrochloride on plasma vitamin B6 metabolism within therapeutic limits (up to 800 mg/day) were investigated. Maximum plasma concentrations of pyridoxal phosphate were attained at relatively low intakes of pyridoxine hydrochloride. Two metabolism thought
Junichi Funami et al.
Biochimica et biophysica acta, 1753(2), 234-239 (2005-10-18)
4-Pyridoxolactonase is involved in the degradation pathway for pyridoxine, a free form of vitamin B6. The gene (mlr6805) encoding the putative 4-pyridoxolactonase of nitrogen fixing symbiotic microorganism Mesorhizobium loti MAFF303099 has been identified based on the genome database. The gene
Saki Nishimura et al.
Journal of nutritional science and vitaminology, 54(1), 18-24 (2008-04-05)
A determination method for individual natural vitamin B(6) compounds was developed. The vitamin B(6) compounds were specifically converted into 4-pyridoxolactone (PAL), a highly fluorescent compound, through a combination of enzymatic reactions and HCl-hydrolysis. PAL was then determined by HPLC. Pyridoxal
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