04632
N-甲基-L-酪氨酸
≥98% (HPLC)
别名:
(S)-3-(4-Hydroxyphenyl)-2-(methylamino)propionic acid, N-Me-Tyr-OH, Surinamine
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关于此项目
经验公式（希尔记法）:
C10H13NO3
化学文摘社编号:
分子量:
195.22
EC Number:
208-670-8
UNSPSC Code:
12352202
PubChem Substance ID:
Beilstein/REAXYS Number:
2646795
MDL number:
InChI key
AXDLCFOOGCNDST-VIFPVBQESA-N
InChI
1S/C10H13NO3/c1-11-9(10(13)14)6-7-2-4-8(12)5-3-7/h2-5,9,11-12H,6H2,1H3,(H,13,14)/t9-/m0/s1
SMILES string
CN[C@@H](Cc1ccc(O)cc1)C(O)=O
assay
≥98% (HPLC)
form
powder or crystals
optical activity
[α]/D +16.0±1.0°, c = 1 in 1 M HCl
composition
carbon, 60.7-62.3% , nitrogen, 6.9-7.5%
color
colorless to white
application(s)
cell analysis
Application
N-Methyl-L-tyrosine was used in experiments as a control group to show that methylation of the imino group in N-p-phenylpropionyl-L-tyrosine eliminates its inhibitory effect on the firing of the giant neurone of the giant African snail.
Biochem/physiol Actions
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Y Ariyoshi et al.
British journal of pharmacology, 77(4), 631-639 (1982-12-01)
1 Inhibitory effects of N-beta-phenylpropionyl-L-tyrosine, N-beta-phenylpropionyl-L-tryptophan and their derivatives on an identifiable giant neurone, TAN (tonically autoactive neurone) of an African giant snail (Achatina fulica Férussac) were examined in an attempt to elucidate which structural features are necessary to produce
D J Gordon et al.
Biochemistry, 40(28), 8237-8245 (2001-07-11)
A potential goal in the prevention or therapy of Alzheimer's disease is to decrease or eliminate neuritic plaques composed of fibrillar beta-amyloid (Abeta). In this paper we describe N-methyl amino acid containing congeners of the hydrophobic "core domain" of Abeta
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