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Merck
CN

06863

Sigma-Aldrich

甘氨酰去氧胆酸

≥96.0% (TLC)

别名:

N-(3α,7β-二羟基-5β-cholan-24-oyl）甘氨酸, N-[(3α, 5β, 7β）-3,7-二羟基-24-氧代胆甾烷-24-基 ] 甘氨酸, GUDCA, 乌索脱氧胆基甘氨酸, 甘氨酰脱氧胆酸

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关于此项目

经验公式（希尔记法）:
C26H43NO5
化学文摘社编号:
64480-66-6
分子量:
449.62
MDL编号:
MFCD00137427
UNSPSC代码:
12161900
PubChem化学物质编号:
329748294
NACRES:
NA.25

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生物来源

synthetic

质量水平

100

方案

≥96.0% (TLC)

表单

powder

官能团

carboxylic acid

SMILES字符串

[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(NCC(O)=O)=O
[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(NCC(O)=O)=O

InChI

1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21+,24+,25+,26-/m1/s1

InChI key

GHCZAUBVMUEKKP-XROMFQGDSA-N

相关类别

应用


  • 甘氨熊去氧胆酸通过抑制血小板中二酰基甘油激酶活性来缓解动脉血栓形成。: 重点介绍了甘氨熊去氧胆酸通过抑制血小板中二酰基甘油激酶活性来缓解动脉血栓形成的治疗潜力（Yang et al., 2024）。

生化/生理作用

来源于酰基甘氨酸的次级胆汁酸。据报道甘氨脱氧胆酸 (GUDCA) 具有细胞保护和抗炎作用。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN5865
BCCK3112
BCCJ6579
BCCD4705
BCCB9011

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Kazuya Maeda et al.
Molecular pharmaceutics, 3(1), 70-77 (2006-05-12)
Ursodeoxycholate (UDCA) is widely used for the treatment of cholestatic liver disease. After oral administration, UDCA is absorbed, taken up efficiently by hepatocytes, and conjugated mainly with glycine to form glycoursodeoxycholate (GUDC) or partly with taurine to form tauroursodeoxycholate (TUDC)
Sandra L Silva et al.
Neuropharmacology, 62(7), 2398-2408 (2012-03-01)
Neuronal oxidative damage and cell death by unconjugated bilirubin (UCB) showed to be mediated by overstimulation of glutamate receptors and nitric oxide (NO) production, which was abrogated by the bile acid glycoursodeoxycholic acid (GUDCA). Microglia, a crucial mediator of CNS
Y Hamada et al.
The Biochemical journal, 283 ( Pt 2), 575-581 (1992-04-15)
The effects were investigated of the choleretic bile salt glycoursodeoxycholate (G-UDCA) and of the cholestatic bile salt taurochenodeoxycholate (T-CDCA) on changes in perfusate Ca2+, glucose and oxygen and in bile calcium and bile flow induced by the administration of (a)
M J Perez et al.
British journal of pharmacology, 162(8), 1686-1699 (2010-12-24)
Mitochondria are involved in the toxicity of several compounds, retro-control of gene expression and apoptosis activation. The effect of mitochondrial genome (mtDNA) depletion on changes in ABC transporter protein expression in response to bile acids and paracetamol was investigated. Hepa
Ewa Ellis et al.
Hepatology (Baltimore, Md.), 38(4), 930-938 (2003-09-27)
Primary human hepatocytes were used to elucidate the effect of individual bile acids on bile acid formation in human liver. Hepatocytes were treated with free as well as glycine-conjugated bile acids. Bile acid formation and messenger RNA (mRNA) levels of
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