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06863

甘氨酰去氧胆酸

≥96.0% (TLC)

别名:

N-(3α,7β-二羟基-5β-cholan-24-oyl）甘氨酸, N-[(3α, 5β, 7β）-3,7-二羟基-24-氧代胆甾烷-24-基 ] 甘氨酸, GUDCA, 乌索脱氧胆基甘氨酸, 甘氨酰脱氧胆酸

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关于此项目

经验公式（希尔记法）:
C26H43NO5
化学文摘社编号:
64480-66-6
分子量:
449.62
UNSPSC Code:
12161900
PubChem Substance ID:
329748294
NACRES:
NA.25
MDL number:
MFCD00137427
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biological source

synthetic

Quality Segment

100

assay

≥96.0% (TLC)

form

powder

functional group

carboxylic acid

InChI

1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21+,24+,25+,26-/m1/s1

InChI key

GHCZAUBVMUEKKP-XROMFQGDSA-N

Application


  • 甘氨熊去氧胆酸通过抑制血小板中二酰基甘油激酶活性来缓解动脉血栓形成。: 重点介绍了甘氨熊去氧胆酸通过抑制血小板中二酰基甘油激酶活性来缓解动脉血栓形成的治疗潜力（Yang et al., 2024）。

Biochem/physiol Actions

来源于酰基甘氨酸的次级胆汁酸。据报道甘氨脱氧胆酸 (GUDCA) 具有细胞保护和抗炎作用。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN5865
BCCK3112
BCCJ6579
BCCD4705
BCCB9011

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实验方案

HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

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Bile Acids Kit for LC-MS

Bile Acids (BA) are synthesized in the liver and play important roles in cholesterol homeostasis, absorption of vitamins and lipids, and various key metabolic processes.

A Roda et al.
The Journal of biological chemistry, 258(10), 6362-6370 (1983-05-25)
The relationship between chemical structure and the concentration at which self-association occurs in water or in 0.15 M Na+ ion was examined for more than 50 bile salts and bile salt analogues varying in substituents on the steroid nucleus or
A Roda et al.
Pharmaceutical research, 11(5), 642-647 (1994-05-01)
A new enteric-coated formulation of sodium ursodeoxycholate was prepared and administered to man. The barrier film disintegrates and releases the drug only at pH > or = 5.5. The sodium salt of glycoursodeoxycholate was also prepared and encapsulated like ursodeoxycholate.
Sandra L Silva et al.
Neuropharmacology, 62(7), 2398-2408 (2012-03-01)
Neuronal oxidative damage and cell death by unconjugated bilirubin (UCB) showed to be mediated by overstimulation of glutamate receptors and nitric oxide (NO) production, which was abrogated by the bile acid glycoursodeoxycholic acid (GUDCA). Microglia, a crucial mediator of CNS
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全球贸易项目编号

货号GTIN
06863-1G04061826268872