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Merck
CN

08161

2-Deoxy-L-ribonic acid lithium salt

≥95.0% (TLC)

别名:

2-Deoxy-L-erythro-pentonic acid lithium salt

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关于此项目

经验公式(希尔记法):
C5H10O5 · xLi+
化学文摘社编号:
分子量:
150.13 (free acid basis)
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25
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assay

≥95.0% (TLC)

optical activity

[α]/D -12.0±2.0°, 24 hr, c = 1 in 1 M HCl

storage temp.

2-8°C

SMILES string

OC[C@H](O)[C@H](O)CC(O)=O

InChI

1S/C5H10O5/c6-2-4(8)3(7)1-5(9)10/h3-4,6-8H,1-2H2,(H,9,10)/t3-,4+/m1/s1

InChI key

VBUWJOHKCBQXNU-DMTCNVIQSA-N

General description

L-Enantiomer of 2-deoxyribonic acid


存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Yuichi Nakajima et al.
International journal of cancer, 119(7), 1710-1716 (2006-04-29)
Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor. 2-Deoxy-D-ribose (D-dRib), the degradation product of thymidine generated by TP activity, has been suggested to be a downstream mediator of
Constantine G Boojamra et al.
Bioorganic & medicinal chemistry letters, 18(3), 1120-1123 (2008-01-01)
GS-9148 (2'-Fd4AP, 4) has been identified as a nucleoside phosphonate reverse transcriptase (RT) inhibitor with activity against wild-type HIV (EC(50)=12 microM). Unlike many clinical RT inhibitors, relevant reverse transcriptase mutants (M184V, K65R, 6-TAMs) maintain a susceptibility to 2'-Fd4AP that is
Yuichi Nakajima et al.
Cancer research, 64(5), 1794-1801 (2004-03-05)
Thymidine phosphorylase (TP) catalyzes the reversible conversion of thymidine to thymine, thereby generating 2-deoxy-D-ribose-1-phosphate, which upon dephosphorylation forms 2-deoxy-D-ribose (D-dRib), a degradation product of thymidine. We have previously shown that D-dRib promotes angiogenesis and chemotaxis of endothelial cells and also



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429058-1G04061825770970
429058-10G04061832100029
08161-10MG04061831598858
08161-50MG04061831598872
08161-250MG04061831598865