08161
2-Deoxy-L-ribonic acid lithium salt
≥95.0% (TLC)
别名:
2-Deoxy-L-erythro-pentonic acid lithium salt
方案
≥95.0% (TLC)
旋光性
[α]/D -12.0±2.0°, 24 hr, c = 1 in 1 M HCl
储存温度
2-8°C
SMILES字符串
OC[C@H](O)[C@H](O)CC(O)=O
InChI
1S/C5H10O5/c6-2-4(8)3(7)1-5(9)10/h3-4,6-8H,1-2H2,(H,9,10)/t3-,4+/m1/s1
InChI key
VBUWJOHKCBQXNU-DMTCNVIQSA-N
一般描述
L-Enantiomer of 2-deoxyribonic acid
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Yuichi Nakajima et al.
International journal of cancer, 119(7), 1710-1716 (2006-04-29)
Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor. 2-Deoxy-D-ribose (D-dRib), the degradation product of thymidine generated by TP activity, has been suggested to be a downstream mediator of
Constantine G Boojamra et al.
Bioorganic & medicinal chemistry letters, 18(3), 1120-1123 (2008-01-01)
GS-9148 (2'-Fd4AP, 4) has been identified as a nucleoside phosphonate reverse transcriptase (RT) inhibitor with activity against wild-type HIV (EC(50)=12 microM). Unlike many clinical RT inhibitors, relevant reverse transcriptase mutants (M184V, K65R, 6-TAMs) maintain a susceptibility to 2'-Fd4AP that is
Yuichi Nakajima et al.
Cancer research, 64(5), 1794-1801 (2004-03-05)
Thymidine phosphorylase (TP) catalyzes the reversible conversion of thymidine to thymine, thereby generating 2-deoxy-D-ribose-1-phosphate, which upon dephosphorylation forms 2-deoxy-D-ribose (D-dRib), a degradation product of thymidine. We have previously shown that D-dRib promotes angiogenesis and chemotaxis of endothelial cells and also
N S Brown et al.
British journal of cancer, 92(9), 1696-1701 (2005-04-21)
Elevated thymidine phosphorylase has been shown to correlate with increased angiogenesis and poor prognosis in many cancers including transitional cell carcinoma of the bladder. In vitro studies have demonstrated that thymidine phosphorylase activity causes cellular oxidative stress and increases secretion
Lesch-Nyhan syndrome: reduced amino acid concentrations in CSF and brain.
R A Harkness
Advances in experimental medicine and biology, 253A, 159-163 (1989-01-01)
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