08486
5-Pyridoxolactone
≥98.5% (HPLC and enzymatic)
别名:
3-Carboxy-4-(hydroxymethyl)-5-hydroxy-6-methylpyridine lactone, 5-Pyridoxic acid γ-lactone, 7-Hydroxy-6-methylfuro[3,4-c]pyridin-3(1H)-one, NSC 15983, NSC 41813
产品名称
5-Pyridoxolactone, ≥98.5% (HPLC and enzymatic)
InChI
1S/C8H7NO3/c1-4-7(10)6-3-12-8(11)5(6)2-9-4/h2,10H,3H2,1H3
InChI key
PPAXBSPBIWBREI-UHFFFAOYSA-N
assay
≥98.5% (HPLC and enzymatic)
98.5-101.5% (T)
form
powder
technique(s)
HPLC: suitable
color
white to light yellow
storage temp.
−20°C
Biochem/physiol Actions
5-Pyridoxolactone is a normal human metabolite of vitamin B6 metabolism.
General description
5-pyridoxolactone is a metabolite of vitamin B6.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Vitamins (2013)
Determination of 5-pyridoxic acid, 5-pyridoxic acid lactone, and other vitamin B6 compounds by cation-exchange high-performance liquid chromatography.
J D Mahuren et al.
Methods in enzymology, 280, 22-29 (1997-01-01)
Identification of 5-pyridoxic acid and 5-pyridoxic acid lactone as metabolites of vitamin B6 in humans.
Mahuren, J. D., et al.
The Journal of Nutritional Biochemistry, 2, 449-453 (1991)
Junichi Funami et al.
Biochimica et biophysica acta, 1753(2), 234-239 (2005-10-18)
4-Pyridoxolactonase is involved in the degradation pathway for pyridoxine, a free form of vitamin B6. The gene (mlr6805) encoding the putative 4-pyridoxolactonase of nitrogen fixing symbiotic microorganism Mesorhizobium loti MAFF303099 has been identified based on the genome database. The gene
Y J Jong et al.
The Journal of biological chemistry, 261(32), 15112-15114 (1986-11-15)
4-Pyridoxolactone and 5-pyridoxolactone, formed by dehydrogenation of pyridoxal or isopyridoxal during the bacterial degradation of vitamin B6 by Pseudomonas MA-1 and Arthrobacter Cr-7, respectively, are hydrolyzed to the corresponding acids by distinct inducible lactonases which were purified to homogeneity. 4-Pyridoxolactonase
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