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Merck
CN

11707

Sigma-Aldrich

巴佛洛霉素B1 来源于链霉菌 属

≥80% (HPLC)

别名:

Setamycin

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关于此项目

经验公式（希尔记法）:
C44H65NO13
化学文摘社编号:
88899-56-3
分子量:
815.99
Beilstein:
4640118
UNSPSC代码:
51102829
PubChem化学物质编号:
329749534
NACRES:
NA.85

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方案

≥80% (HPLC)

表单

powder or crystals

颜色

white to yellow

抗生素抗菌谱

Gram-positive bacteria
fungi

作用机制

enzyme | inhibits

运输

wet ice

储存温度

−20°C

SMILES字符串

CO[C@H]1C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)\C=C\C(=O)NC3=C(O)CCC3=O)[C@H](C)[C@H](O2)C(C)C

InChI

1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)/b14-12-,18-17+,24-13+,25-20+,34-21-/t26-,27+,28-,29-,30-,33-,35+,39-,40+,41+,42+,44+/m0/s1

InChI key

KFUFLYSBMNNJTF-HHZDOKBSSA-N

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一般描述

Chemical structure: macrolide

应用

Bafilomycin B1 is a toxic macrolide antibiotic used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis .

生化/生理作用

Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase) and is used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis.
Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase). Bafilomycin B1′s activity results from the presence of a large macrocyclic lactone ring to which deoxy sugars may attach.

包装

1MG

其他说明

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Moisture sensitive. Keep in a dry place.

免责声明

Fatal if swallowed.
Bafilomycin B1 is fatal if it is inhaled, swallowed, or if it comes in contact with skin.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H310 + H330

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000157372
0000107301
099M4890V
049M4754V

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P Melin et al.
Microbiology (Reading, England), 145 ( Pt 5), 1115-1122 (1999-06-22)
In natural environments bacteria and filamentous fungi often compete for the same resources. Consequently, production of antibiotic secondary metabolites and defence mechanisms against these compounds have evolved in these organisms. An experimental model has been developed to study the response
Wei Zhang et al.
Chembiochem : a European journal of chemical biology, 14(3), 301-306 (2013-01-31)
New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii
R Kollmann et al.
Biochimica et biophysica acta, 1143(1), 62-66 (1993-06-10)
The ATP-generating system described by Hugenholtz, J., Hong, J.-S. and Kaback, H.R. ((1981) Proc. Natl. Acad. Sci. USA 78, 3446-3449) has been used to synthesize ATP up to 1.8 mM in right-side-out membrane vesicles from Escherichia coli. This ATP level
J Miguel Cordeiro et al.
Journal of molecular neuroscience : MN, 30(1-2), 41-44 (2006-12-29)
Rapid secretion relies on the occurrence of spike-like Ca2+ transients in active zones (Llinás et al., 1992; Yazejian et al., 2000; Dunant and Bloc, 2003). Presynaptic Ca2+ nanodomains are to be restricted both in time and in space as to
Tim Schuhmann et al.
The Journal of antibiotics, 60(1), 52-60 (2007-03-30)
The microbial macrolides bafilomycin A1, B, and concanamycin A from Streptomyces spp. are potent and specific inhibitors of V-ATPases. The question of the biosynthetic origin of the two uncommon "glycolate units" of each of the macrolide structures was addressed by
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