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Merck
CN

11707

巴佛洛霉素B1 来源于链霉菌 属

≥80% (HPLC)

别名:

Setamycin

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关于此项目

经验公式（希尔记法）:
C44H65NO13
化学文摘社编号:
88899-56-3
分子量:
815.99
NACRES:
NA.85
PubChem Substance ID:
329749534
UNSPSC Code:
51102829
Beilstein/REAXYS Number:
4640118

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InChI

1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)/b14-12-,18-17+,24-13+,25-20+,34-21-/t26-,27+,28-,29-,30-,33-,35+,39-,40+,41+,42+,44+/m0/s1

SMILES string

CO[C@H]1C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(=O)\C=C\C(=O)NC3=C(O)CCC3=O)[C@H](C)[C@H](O2)C(C)C

InChI key

KFUFLYSBMNNJTF-HHZDOKBSSA-N

assay

≥80% (HPLC)

form

powder or crystals

color

white to yellow

antibiotic activity spectrum

Gram-positive bacteria, fungi

mode of action

enzyme | inhibits

shipped in

wet ice

storage temp.

−20°C

General description

Chemical structure: macrolide

Application

Bafilomycin B1 is a toxic macrolide antibiotic used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis .

Biochem/physiol Actions

Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase) and is used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis.
Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase). Bafilomycin B1′s activity results from the presence of a large macrocyclic lactone ring to which deoxy sugars may attach.

Packaging

1MG

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Moisture sensitive. Keep in a dry place.

Disclaimer

Fatal if swallowed.
Bafilomycin B1 is fatal if it is inhaled, swallowed, or if it comes in contact with skin.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000157372
0000107301
099M4890V
049M4754V

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P Melin et al.
Molecular genetics and genomics : MGG, 267(6), 695-702 (2002-09-11)
Competition between microbes is common to all ecosystems, but the exact nature of the competition is in most cases unknown. We have previously studied the antagonism between Streptomyces halstedii and several fungi at both the organismal and gene expression levels.
S Naganuma et al.
Biochimica et biophysica acta, 1126(1), 41-48 (1992-06-05)
Two microbial metabolites, bafilomycin B1 and destruxin E, have been found to inhibit significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets at 3 nM and 0.5 microM, respectively, in macrophage J774. The incorporation of [14C]oleate into cholesteryl
Tim Schuhmann et al.
The Journal of antibiotics, 60(1), 52-60 (2007-03-30)
The microbial macrolides bafilomycin A1, B, and concanamycin A from Streptomyces spp. are potent and specific inhibitors of V-ATPases. The question of the biosynthetic origin of the two uncommon "glycolate units" of each of the macrolide structures was addressed by
R Kollmann et al.
Biochimica et biophysica acta, 1143(1), 62-66 (1993-06-10)
The ATP-generating system described by Hugenholtz, J., Hong, J.-S. and Kaback, H.R. ((1981) Proc. Natl. Acad. Sci. USA 78, 3446-3449) has been used to synthesize ATP up to 1.8 mM in right-side-out membrane vesicles from Escherichia coli. This ATP level
Absolute configurations of macrolide antibiotics of the bafilomycin and leucanicidin groups.
M G O'Shea et al.
The Journal of antibiotics, 50(12), 1073-1077 (1998-03-25)
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