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Merck
CN

12266

N-[4-(2-Benzimidazolyl)phenyl]maleimide

BioReagent, suitable for fluorescence, ≥98.0% (HPLC)

别名:

BIPM

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关于此项目

经验公式（希尔记法）:
C17H11N3O2
化学文摘社编号:
27030-97-3
分子量:
289.29
EC Number:
248-173-3
UNSPSC Code:
12352200
PubChem Substance ID:
57646978
Beilstein/REAXYS Number:
755407
MDL number:
MFCD00042767

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product line

BioReagent

assay

≥98.0% (HPLC)

form

solid

solubility

H2O: soluble, acetone: soluble

fluorescence

λex 315 nm; λem 365 nm (after derivatization with 2-mercaptoethanol)

suitability

suitable for fluorescence

SMILES string

O=C1C=CC(=O)N1c2ccc(cc2)-c3nc4ccccc4[nH]3

InChI

1S/C17H11N3O2/c21-15-9-10-16(22)20(15)12-7-5-11(6-8-12)17-18-13-3-1-2-4-14(13)19-17/h1-10H,(H,18,19)

InChI key

NZDOXVCRXDAVII-UHFFFAOYSA-N

Other Notes

Fluorescent probe in proteins, used for microfluorometry of thiol compounds (detection limit: 10-6 m thiol conc.); Review

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

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Fluorescent thiol reagents. V. Microfluorometry of thiol compounds with a fluorescent-labeled maleimide.
T Sekine et al.
Analytical biochemistry, 48(2), 557-568 (1972-08-01)
S Inoue et al.
Japanese journal of pharmacology, 43(1), 107-111 (1987-01-01)
Trypsin treatment of N-[p-(2-benzimidazolyl)phenyl]maleimide modified enzyme caused a marked reduction in Na+,K+-ATPase activity and in the amount of the alpha-chain, which contains the phosphorylation and ouabain binding sites. However, these preparations retained nearly 90% of the ouabain binding capacity and
Takao Hibi et al.
Acta crystallographica. Section D, Biological crystallography, 58(Pt 2), 316-318 (2002-01-25)
Escherichia coli B gamma-glutamylcysteine synthetase (gammaGCS) catalyzes the ATP-dependent coupling of L-Glu and L-Cys to form the glutathione precursor gamma-L-Glu-Cys and is a target for development of potential therapeutic agents. By introducing four point mutations of surface-exposed cysteine residues to
Luciano Giromini et al.
Journal of mental health (Abingdon, England), 26(6), 523-529 (2017-06-27)
Emotional intelligence (EI) is a field of study that is receiving increasingly attention in the literature, due to its relevance to a series of aspects of human psychological and social functioning. This study used archival data from an Italian sample
P K Jha et al.
Biochemistry, 35(34), 11026-11035 (1996-08-27)
Contraction of vertebrate striated muscle is regulated by the strong Ca(2+)-dependent interaction between troponin I (TnI) and troponin C (TnC). To critically evaluate this interaction, we generated four recombinant deletion fragments of rabbit fast skeletal TnI: the NH2-terminal fragment (TnI1-94)
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