158240
1-硝基吡咯烷
99%
别名:
N-亚硝基吡咯烷, NPYR
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关于此项目
经验公式（希尔记法）:
C4H8N2O
化学文摘社编号:
分子量:
100.12
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
213-218-8
MDL number:
InChI key
WNYADZVDBIBLJJ-UHFFFAOYSA-N
InChI
1S/C4H8N2O/c7-5-6-3-1-2-4-6/h1-4H2
SMILES string
O=NN1CCCC1
assay
99%
bp
214 °C (lit.)
density
1.085 g/mL at 25 °C (lit.)
Application
1-硝基吡咯烷可用于研究致癌物和癌症。已在大鼠中检测了体内亚硝胺的代谢。1-硝基吡咯烷已用于研究鸡胚中的一氧化氮和自发收缩活动。
Biochem/physiol Actions
在小鼠中诱发肝细胞癌和肺腺瘤。形成主要导致 A：T 到 G：C 突变的 DNA 加合物。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
208.4 °F - closed cup
flash_point_c
98 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
此项目有
M Nakata et al.
Journal of biochemistry, 122(1), 188-192 (1997-07-01)
Aromatic nitroso-compounds such as nitrosobenzene inhibited the respiratory burst of intact neutrophils induced by various stimulants, including phorbol 12-myristate 13-acetate and a chemotactic peptide. The compounds also inhibited NADPH-dependent oxygen consumption by cell-free preparations of neutrophils. This indicates that nitroso-compounds
Nuria Arranz et al.
Journal of applied toxicology : JAT, 28(6), 788-796 (2008-03-18)
The aim of this study was to evaluate the effect of vitamin C towards N-nitrosopyrrolidine (NPYR)- and N-nitrosodimethylamine (NDMA)-induced apoptosis in human hepatoma (HepG2) and leukemia (HL-60) cell lines using flow cytometry analysis and the terminal deoxynucleotidyl transferase-mediated dUTP nick
Ana Paula M Loureiro et al.
Chemical research in toxicology, 22(10), 1728-1735 (2009-09-19)
The well established rat hepatocarcinogen N-nitrosopyrrolidine (NPYR, 1) requires metabolic activation to DNA adducts to express its carcinogenic activity. Among the NPYR-DNA adducts that have been identified, the cyclic 7,8-butanoguanine adduct 2-amino-6,7,8,9-tetrahydro-9-hydroxypyrido[2,1-f]purine-4(3H)-one (6) has been quantified using moderately sensitive methods
N Arranz et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 45(9), 1662-1669 (2007-04-17)
The aim of this study was to investigate the protective effect of organosulfur compounds towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. N-Nitrosopyrrolidine (NPYR) and N-nitrosodimethylamine (NDMA) incubated with formamidopyrimidine-DNA glycosylase (Fpg), caused a significant increase in
Sadagopan Krishnan et al.
Chemical communications (Cambridge, England), (17)(17), 1713-1715 (2007-04-26)
We report for the first time voltammetric/electrochemiluminescent sensors applied to predict genotoxicity of N-nitroso compounds bioactivated by human cytochrome P450 enzymes.
商品
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
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