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Merck
CN

174R-1

CD74 (EP167) Rabbit Monoclonal Primary Antibody

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关于此项目

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP167, monoclonal
Application:
IHC (p)
Citations:
1

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP167, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (174R-14), vial of 0.1 mL concentrate Research Use Only (174R-14-RUO), vial of 0.5 mL concentrate (174R-15), vial of 1.0 mL concentrate (174R-16), vial of 1.0 mL concentrate Research Use Only (174R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (174R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (174R-17), vial of 7.0 mL pre-dilute ready-to-use (174R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (174R-18-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)

isotype

IgG

control

lymph node, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... CD74(972)

General description

The CD74 antigen represents a membrane-bound subunit of the MHC Class II-associated invariant chain that is encoded by the gene located on Chromosome 5. The antibody recognizes nuclear and cytoplasmic antigens of MW 35 kD and 31 kD respectively. Anti-CD74 stains predominantly germinal center lymphocytes and those in the mantle cell region of the lymph node. It stains the cell membrane but a paranuclear globular labeling is also noted. Plasma cells are not labeled. Thymocytes are negative but dendritic cells are often labeled by anti-CD74. Anti-CD74 labels about 90% of low grade B-cell lymphomas and 20% of low grade T-cell lymphomas. In high-grade lymphomas the discriminatory power (B-cell vs. T-cell) is diminished. Reed-Sternberg cells are also labeled in approximately 60% of cases.1

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note


IVD
IVD
IVD
RUO

Other Notes

CD74 Positive Control Slides, Product No. 174S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Manual of Diagnostic Antibodies for Immunohistology (1999)

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