(2-Carboxyethyl)-β-cyclodextrin sodium salt

(2-Carboxyethyl)-β-cyclodextrin sodium is a derivative of β-cyclodextrin, typically used to enhance the properties of the latter such as stability and water solubility. β-cyclodextrin has garnered increased research attention due to its potential application as host-guest inclusion complex used in the pharmaceutical industry and as antibacterial material utilized in food and pharmacy.

(2-Carboxyethyl)-β-cyclodextrin sodium salt may be used:

• As a chiral selector for the enantioseparation of cinacalcet impurities and fenamiphos pesticide by capillary zone electrophoresis and ³¹P nuclear magnetic resonance spectroscopy (³¹P NMR), respectively.
• To form an inclusion complex with carvacrol for subsequent use in the antibacterial multilayer construction with chitosan, loaded onto poly(L-lactic acid) (PLLA).

Cyclodextrins (CD) are cyclic oligosaccharides composed of D-glucose units connected via α(1→4) glycosidic bonds. Common cyclodextrins contain six (α-CD); seven (β-CD) or eight (gamma-CD) D-glucose units. Cyclodextrins are sometimes derivitized through esterification at positions two, three and/or six.(2-Carboxyethyl)-β-cyclodextrin and other negative charge derivitized cyclodextrins are used in chiral recognition and resolution of cationic racemic mixtures of enantiomers using capillary electrophoresis.

average degree of substitution, DS ~3

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