biological source
rabbit
conjugate
unconjugated
antibody form
Ig fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (222A-14), vial of 0.5 mL concentrate (222A-15), bottle of 1.0 mL predilute (222A-17), vial of 1.0 mL concentrate (222A-16), bottle of 7.0 mL predilute (222A-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
control
tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
General description
Alpha-1-Antichymotrypsin Primary Antibody reacts with histiocytes and histiocytic neoplasms. Its major application is defining the presence of Alpha-1-Antichymotrypsin in histiocytes and tumors derived from them. In eosinophilic granuloma and malignant histiocytosis, the reaction for this marker is heterogeneous in intensity and distribution. In fibrous histiocytomas on the other hand, a diffuse homogeneous reaction may be observed. Acinar tumors of the pancreas and salivary gland may also exhibit Alpha-1-Antichymotrypsin positivity.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
A-1-Antichymotrypsin Positive Control Slides , Product No. 222S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
A Fabre et al.
Virchows Archiv : an international journal of pathology, 438(3), 312-315 (2001-04-24)
We describe a purely intraductal acinar cell carcinoma involving branch ducts of the pancreas in a 74-year-old man, which presented as recurrent episodes of acute pancreatitis. Endoscopic ultrasound examination revealed an intraductal mass bulging into the main pancreatic duct suggesting
Alpha 1-antitrypsin in human macrophages.
P Isaacson et al.
Lancet (London, England), 2(8149), 964-965 (1979-11-03)
I Reintoft et al.
Human pathology, 10(4), 419-424 (1979-07-01)
In 10 of 56 patients with primary liver carcinoma the nontumorous hepatocytes contained diastase resistant, periodic acid-Schiff positive and alpha-1-antitrypsin positive (immunoperoxidase technique) globules. This is a frequency of 18 per cent among patients with liver carcinoma against 6 per
Immunohistochemistry of liver in alpha1-antitrypsin deficiency. A comparative study.
P E Palmer et al.
American journal of clinical pathology, 62(3), 350-354 (1974-09-01)
L G Kindblom et al.
Human pathology, 13(9), 834-840 (1982-09-01)
The aim of this study was to localize alpha 1-antitrypsin, ferritin, and lysozyme by means of the indirect immunoperoxidase technique and to evaluate the significance of these antigens as markers of histiocytic differentiation in tumors of a supposed dual fibroblastic-histiocytic
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