biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
E89, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (230R-14)
vial of 0.5 mL concentrate (230R-15)
bottle of 1.0 mL predilute (230R-17)
vial of 1.0 mL concentrate (230R-16)
bottle of 7.0 mL predilute (230R-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG
control
appendix, breast
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Caldesmon is a regulatory protein that plays a role in smooth muscle contraction with actin, myosin, tropomyosin, and calmodulin. Anti-caldesmon antibody labels smooth muscle and tumors of smooth muscle. It also typically shows expression in epithelioid mesothelioma but not in ovarian serous carcinoma.
Other Notes
Caldesmon Positive Control Slides, Product No. 230S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
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此项目有
W Glenn McCluggage
Advances in anatomic pathology, 11(3), 162-171 (2004-04-21)
In recent years there have been a plethora of publications regarding the value of immunohistochemical studies in diagnosis in gynecological pathology. In many instances, papers are published initially that suggest that a certain antibody or panel of antibodies is of
Camilla E Comin et al.
The American journal of surgical pathology, 30(4), 463-469 (2006-04-21)
Although a large number of immunohistochemical markers that can facilitate the differential diagnosis between epithelioid pleural mesothelioma and lung adenocarcinoma involving the pleura have proven to be valuable, no single antibody has demonstrated absolute sensitivity and/or specificity in making this
Markku Miettinen et al.
Archives of pathology & laboratory medicine, 130(10), 1466-1478 (2006-11-09)
Gastrointestinal stromal tumors (GISTs) are specific, generally Kit (CD117)-positive, mesenchymal tumors of the gastrointestinal tract encompassing a majority of tumors previously considered gastrointestinal smooth muscle tumors. They are believed to originate from interstitial cells of Cajal or related stem cells.
K Watanabe et al.
Human pathology, 30(4), 392-396 (1999-04-20)
h-Caldesmon (h-CD) is a protein combined with actin and tropomyosin that regulates cellular contraction. h-CD has been thought to be expressed exclusively in vascular and visceral smooth muscle cells (SMC). We examined h-CD expression immunohistochemically in tumors with SMC and
Camilla E Comin et al.
The American journal of surgical pathology, 31(8), 1139-1148 (2007-08-02)
Distinguishing between epithelioid peritoneal mesothelioma and papillary serous carcinomas involving the peritoneum may be very difficult, owing to overlapping morphologic features. Immunohistochemistry may facilitate establishing a correct diagnosis, but, as no single antibody has demonstrated absolute sensitivity and specificity for
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