biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
EP15, monoclonal
description
(For In Vitro Diagnostic Use in Select Regions (See Chart))
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (243R-14)
vial of 0.5 mL concentrate (243R-15)
bottle of 1.0 mL predilute (243R-17)
vial of 1.0 mL concentrate (243R-16)
bottle of 7.0 mL predilute (243R-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG
control
skeletal muscle
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... DES(1674)
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
Anti-desmin detects a protein that is expressed by cells of normal smooth, skeletal, and cardiac muscles. It has been suggested that desmin is primarily located at or near the periphery of Z lines in striated muscle fibrils. In smooth muscle, desmin interconnects cytoplasmic dense bodies with membrane bound dense plaques. Anti-desmin reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin. This antibody is used to demonstrate the myogenic components/derivation of tumors.1,2 Desmin can also be present in myofibroblasts and be focally positive in desmoid fibromatosis.3
Other Notes
Desmin Positive Control Slides, Product No. 243S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
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此项目有
M Altmannsberger et al.
The American journal of pathology, 118(1), 85-95 (1985-01-01)
Putative human rhabdomyosarcoma (RMS) has been divided into two groups according to desmin content. Twenty-five tumors with histologic features consistent with but not necessarily sufficient to prove a diagnosis of RMS were desmin-positive. More than 95% of the tumor cells
Umio Yamaguchi et al.
Virchows Archiv : an international journal of pathology, 445(2), 142-150 (2004-07-03)
To confirm the usefulness of an immunohistochemical panel of antibodies for KIT (c-kit/CD117), CD34, desmin, smooth-muscle actin (SMA), h-caldesmon (HCD), S-100 protein, neuron-specific enolase (NSE), and beta-catenin, 297 mesenchymal and peripheral nerve-sheath tumors of the gastrointestinal tract and intra-abdominal locations
E Debus et al.
The EMBO journal, 2(12), 2305-2312 (1983-01-01)
A set of monoclonal antibodies to desmin has been isolated from a fusion of mouse myeloma cells with spleen cells from mice immunized with purified porcine desmin. Eleven group I antibodies recognized desmin in the immune blot, and using defined
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