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Merck
CN

357R-1

Sigma-Aldrich

TCL1 (EP105) Rabbit Monoclonal Primary Antibody

别名:

T-cell leukemia/lymphoma protein 1

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关于此项目

UNSPSC代码:
12352203

主要文件

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生物来源

rabbit

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP105, monoclonal

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate Research Use Only (357R-14-RUO)
vial of 0.1 mL concentrated (357R-14)
vial of 0.5 mL concentrated (357R-15)
vial of 1.0 mL concentrate Research Use Only (357R-16-RUO)
vial of 1.0 mL concentrated (357R-16)
vial of 1.0 mL pre-dilute Research Use Only (357R-17-RUO)
vial of 1.0 mL predilute ready-to-use (357R-17)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (357R-18-RUO)
vial of 7.0 mL predilute ready-to-use (357R-18)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200 (concentrated)

控制

follicular lymphoma, tonsil

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic (tonsil), nuclear (tonsil, follicular lymphoma)

基因信息

human ... TCL1A(8115)

一般描述

T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene. TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell lymphoma. TCL1 binds to a novel site in the pleckstrin homology (PH) domain, resulting in activation and nuclear translocation of Akt by overexpressed TCL1 which may promote an anti-apoptotic response; this may normally serve to promote growth during development but may lead to malignancy when TCL1 is overexpressed. TCL1 is expressed in differentiated B-cells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. TCL1 is down-regulated in the latest stage of B-cell differentiation. TCL1 is overexpressed in Burkitt lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, and follicular lymphoma.

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

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分析说明

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
TCL1 Positive Control Slides, Product No. 357S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000138420
0000117692
0000117691
0000117669
0000117696

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J Roos et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 69(2), 59-66 (2001-12-26)
TCL1, MTCP1 and TCL1b are three members of a new family of oncogenes that are expressed in T cell leukemias of ataxia telangiectasia patients (T-PLL, T-CLL). TCL1 is located at 14q32.1 and activated by juxtaposition to the alpha/delta-locus at 14q11
Yuri Pekarsky et al.
Hematology/oncology clinics of North America, 18(4), 863-879 (2004-08-25)
Mature leukemias and lymphomas are a heterogeneous group of lymphoproliferative neoplasias characterized by the accumulation of mature lymphocytes in lymph nodes, other lymphoid tissues, and peripheral blood. In this article we discuss molecular mechanisms leading to the pathogenesis of two
Y Pekarsky et al.
Oncogene, 20(40), 5638-5643 (2001-10-19)
The TCL1 locus on human chromosome 14q32.1 is activated in T-cell leukemias by translocations and inversions that juxtapose it to regulatory elements of T-cell receptor genes. We isolated and characterized four genes at this locus, TCL1 and TCL1b (T-cell leukemia/lymphoma
J Takizawa et al.
Japanese journal of cancer research : Gann, 89(7), 712-718 (1998-09-17)
The TCL1 gene was recently cloned as a candidate target within the 14q32.1 breakpoint cluster region observed in T-cell malignancies. We examined the TCL1 gene expression in 21 patients with adult T-cell leukemia (ATL) and 5 cell lines, because ATL
Scott J Rodig et al.
The American journal of surgical pathology, 32(1), 113-122 (2007-12-29)
The distinction between Burkitt (BL) or atypical Burkitt/Burkitt-like lymphomas harboring a MYC translocation (MYC+) and diffuse large B-cell lymphomas (DLBCLs) with high proliferation fractions but without a MYC translocation (MYC-) can be difficult using standard morphologic and immunohistochemical criteria. Recently
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