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Dihydrofolate Reductase from bovine liver

Name: Dihydrofolate Reductase from bovine liver
Brand: SIGMA

~8 U/mL, ammonium sulfate suspension, off-white

别名:

Tetrahydrofolate Dehydrogenase

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关于此项目

化学文摘社编号:

9002-03-3

UNSPSC Code:

12352204

NACRES:

NA.54

EC 号:

1.5.1.3 (BRENDA, IUBMB)

MDL number:

MFCD00130955

Specific activity:

≥6 U/mg protein

Biological source:

bovine liver

Concentration:

~8 U/mL

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属性

biological source

bovine liver

form

ammonium sulfate suspension

specific activity

≥6 U/mg protein

concentration

~8 U/mL

color

off-white

density

1.2 g/mL at 20 °C

storage temp.

2-8°C

说明

Application

Dihydrofolate reductase (DHFR) is involved in the synthesis of purines, thymidine and glycine in folate metabolism. DHFR, from bovine liver, is used for methotrexate analysis . DHFR is useful to study various cancers such as sarcomas, leukemias and head and neck cancers .

Biochem/physiol Actions

Dihydrofolate reductase (DHFR) reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor. The binding of antitumor agents, such as methotrexate, to DHFR prevents the formation of reduced folates, which are essential for DNA synthesis .

Physical form

Suspension in 3.6 M ammonium sulfate solution, pH 7.0

Other Notes

In folate metabolism for the synthesis of purines, thymidine and glycine

1 U corresponds to the amount of enzyme which converts 1 μmol 7,8-dihydrofolate and NADPH to 5,6,7,8-tetrahydrofolate and NADP per minute at pH 6.5 and 25 °C

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存储类别

10 - Combustible liquids

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)

Not applicable

PPE（个人防护设备）

Eyeshields, Gloves

历史批次信息供参考:

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