biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
SP49, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (394R-14), vial of 0.5 mL concentrate (394R-15), bottle of 1.0 mL predilute (394R-17), vial of 1.0 mL concentrate (394R-16), bottle of 7.0 mL predilute (394R-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG
control
cervical intraepithelial neoplasia – high grade, tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... STMN1(3925)
General description
The distinction between high grade cervical intraepithelial neoplasia (CIN2/3) from low grade cervical intraepithelial neoplasia (CIN1) is clinically significant with treatment recommendations linked specificallyto risk of cancer or CIN3 outcome. CIN1 will progress into invasive carcinoma in <1% of cases and is typically managed with Papanicolaou smear follow-up, whereas CIN2/3 has a 5% to 20% risk of progression1 and is usually treated with an excisional procedure (loop electrosurgical excision procedure or cone biopsy).1 Stathmin, also referred to as Stathmin-1 and oncoprotein18, is a ubiquitous microtubule-destabilizing protein shown to be important during mitosis and has been implicated as a regulator of cell motility and migration.
Recent studies show anti-stathmin is positive in 24/82 (29%) CINs with differential expression based on the grade of the lesion as 5/56 (9%) CIN1, 5/11 (45%) CIN2, and 14/15 (93%) CIN3; whereas, anti-p16 staining of the same cases was immuno-reactive in 66/83 (80%) CINs, including 40/56 (71%) CIN1, 11/11 (100%) CIN2, and 15/16 (94%) CIN3. Anti-stathmin shows similar sensitivity for CIN3 to anti-p16 (93% vs 94%) although it drops off for CIN2 (73% vs 96%). The specificity of anti-stathmin for both CIN2/3 (94%) and CIN3 (89%) is higher than that of anti-p16 (44% and 39%, respectively). Anti-Stathmin stains basal layer of normal benign ectocervix. A well-oriented fragment of cervix tissue would increase the accuracy of diagnosis. In conclusion, based on recent studies, anti-stathmin has a higher specificity relative to anti-p16; therefore, anti-stathmin has major potential as a diagnostic marker in CIN classification over anti-p16.
Recent studies show anti-stathmin is positive in 24/82 (29%) CINs with differential expression based on the grade of the lesion as 5/56 (9%) CIN1, 5/11 (45%) CIN2, and 14/15 (93%) CIN3; whereas, anti-p16 staining of the same cases was immuno-reactive in 66/83 (80%) CINs, including 40/56 (71%) CIN1, 11/11 (100%) CIN2, and 15/16 (94%) CIN3. Anti-stathmin shows similar sensitivity for CIN3 to anti-p16 (93% vs 94%) although it drops off for CIN2 (73% vs 96%). The specificity of anti-stathmin for both CIN2/3 (94%) and CIN3 (89%) is higher than that of anti-p16 (44% and 39%, respectively). Anti-Stathmin stains basal layer of normal benign ectocervix. A well-oriented fragment of cervix tissue would increase the accuracy of diagnosis. In conclusion, based on recent studies, anti-stathmin has a higher specificity relative to anti-p16; therefore, anti-stathmin has major potential as a diagnostic marker in CIN classification over anti-p16.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Stathmin Positive Control Slides, Product No. 394S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
K J Syrjänen
European journal of obstetrics, gynecology, and reproductive biology, 65(1), 45-53 (1996-03-01)
Because of the fact that any meaningful classification should bear a close relationship to the biological behavior of the lesions, the usefulness of all new classifications of cervical precancer lesions can only be established by well controlled prospective follow-up studies.
Bellal Joseph et al.
American journal of surgery, 207(1), 89-94 (2013-10-15)
Patients with fatal gunshot wounds (GSWs) to the head often have poor outcomes but are ideal candidates for organ donation. The purpose of this study was to evaluate the effects of aggressive management on organ donation in patient with fatal
Barbara Belletti et al.
Expert opinion on therapeutic targets, 15(11), 1249-1266 (2011-10-08)
Stathmin is a microtubule-destabilizing phosphoprotein, firstly identified as the downstream target of many signal transduction pathways. Several studies then indicated that stathmin is overexpressed in many types of human malignancies, thus deserving the name of Oncoprotein 18 (Op18). At molecular
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