biological source
mouse
conjugate
unconjugated
antibody form
diluted ascites fluid
antibody product type
primary antibodies
clone
44, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (400M-14), vial of 0.5 mL concentrate (400M-15), bottle of 1.0 mL predilute (400M-17), vial of 1.0 mL concentrate (400M-16), bottle of 7.0 mL predilute (400M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG1
control
solitary fibrous tumor
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... ALDH1A1(216)
General description
ALDH1A1 belongs to the ALDH enzymes, a family of evolutionarily conserved enzymes comprised of 19 isoforms that are localized in the cytoplasm, mitochondria or nucleus. ALDH1A1 is predominantly expressed in the epithelium of testis, brain, eye, liver, kidney, as well as neural and hematopoietic stem cells. Recently, it has been reported that high ALDH1A1 mRNA expression was seen in solitary fibrous tumor (SFT) and hemangiopericytoma (HPC), compared to meningiomas and synovial sarcomas. An immunohistochemical study with ALDH1 A1 antibody in 243 meningeal tumors (tissue microarray), including 25 central nervous system SFTs, 13 extrameningeal SFTs, 55 central nervous system HPCs, 163 meningiomas, and 98 synovial sarcomas found that 21 of 25 meningeal SFTs (84%), 11 of 13 extrameningeal SFTs (84.6%), and 18 of 24 (85.4%) meningeal HPCs were positive with anti-ALDH1A1 antibody. Anti-ALDH1A1 can be combined with anti-CD34 to aid in the differentiation between SFT, HPC, meningioma, and synovial sarcoma. 24/25 (96%) meningeal SFTs and 54/55 (98%) meningeal HPCs were positive for ALDH1A1 and/or CD34 whereas only 10/163 (6%) meningiomas and 7/98 (7%) synovial sarcomas were positive for ALDH1A1 and/or CD34. Anti-ALDH1A1 IHC has been recommended for routine use in association with anti-CD34 for the differentiation among SFT, HPC, meningioma, and synovial sarcoma.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
ALDH1A1 Positive Control Slides, Product No. 400S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Paola Marcato et al.
Cell cycle (Georgetown, Tex.), 10(9), 1378-1384 (2011-05-10)
Recent evidence suggests that enhanced aldehyde dehydrogenase (ALDH) activity is a hallmark of cancer stem cells (CSC) measurable by the aldefluor assay. ALDH1A1, one of 19 ALDH isoforms expressed in humans, was generally believed to be responsible for the ALDH
Corinne Bouvier et al.
Acta neuropathologica communications, 1, 10-10 (2013-11-21)
Solitary Fibrous Tumours (SFT) and haemangiopericytomas (HPC) are rare meningeal tumours that have to be distinguished from meningiomas and more rarely from synovial sarcomas. We recently found that ALDH1A1 was overexpressed in SFT and HPC as compared to soft tissue
John P Chute et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(31), 11707-11712 (2006-07-22)
Aldehyde dehydrogenase (ALDH) is an enzyme that is expressed in the liver and is required for the conversion of retinol (vitamin A) to retinoic acids. ALDH is also highly enriched in hematopoietic stem cells (HSCs) and is considered a selectable
商品
AldeRed™ 588-A detects ALDH activity in cancer stem cells, aiding in cancer research.
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