生物来源
human bone (osteoarthritic)
质量水平
包装
pkg of 500,000 cells
制造商/商品名称
Cell Applications, Inc
生长模式
Adherent
核型
2n = 46
形态学
osteoblast
技术
cell culture | mammalian: suitable
相关疾病
arthritis
运输
dry ice
储存温度
−196°C
一般描述
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Human Osteoblasts-Osteoarthritis, HOb-OA, are isolated from bone of patients with osteoarthritis (OA) and provide an excellent model system to study the patophisiology of that disease in vitro, including matrix mineralization, effects of inflammatory mediators and bone morphogenic proteins, physiological control of bone remodeling and regulation of bone metabolism.
Characterization: Positive for bone mineralization.
Human Osteoblasts-Osteoarthritis, HOb-OA, are isolated from bone of patients with osteoarthritis (OA) and provide an excellent model system to study the patophisiology of that disease in vitro, including matrix mineralization, effects of inflammatory mediators and bone morphogenic proteins, physiological control of bone remodeling and regulation of bone metabolism.
Characterization: Positive for bone mineralization.
应用
model system to study the pathophisiology of osteoarthritis, matrix mineralization, effects of inflammatory mediators, bone morphogenic proteins, bone remodeling and metabolism
生化/生理作用
Bone
制备说明
- 2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
- Can be cultured at least 10 doublings
Please refer to the HOb-OA Culture Protocol.
其他说明
Basal Medium containing 10% FBS & 10% DMSO
免责声明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Xiangxiang Sun et al.
International journal of biological sciences, 16(6), 994-1009 (2020-03-07)
Osteoarthritis (OA) is a common type of arthritis. Chronic inflammation is an important contributor to the pathogenesis of OA. The maturation and secretion of proinflammatory cytokines are controlled by inflammasomes, especially NLRP1 (NLR Family Pyrin Domain Containing 1) and NLRP3.
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