410R-1
Cytokeratin 10 (EP97) Rabbit Monoclonal Primary Antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352202
Conjugate:
unconjugated
Clone:
EP97, monoclonal
Application:
IHC (p)
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
EP97, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (410R-14), vial of 0.5 mL concentrate (410R-15), bottle of 1.0 mL predilute (410R-17), vial of 1.0 mL concentrate (410R-16), bottle of 7.0 mL predilute (410R-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG
control
squamous cell carcinoma
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... KRT10(3858)
General description
Cytokeratin 10 (CK10) belongs to type I and acidic keratin family. It is low molecular weight keratin that is usually expressed in suprabasal keratinocytes and can also be seen in suprabasal cells of internal noncornifying, stratified squamous epithelia.In addition, CK10 is reported to be a typical component of cells of eccrine sweat gland ducts and sebaceous cells.Anti-CK10 is helpful in the identification of well differentiated squamous cell carcinoma derived from skin or from internal organs.However, CK10 was found to be sparse in poorly differentiated squamous cell carcinoma, even though it has been reported that focal CK10 expression has been found in 50% of cases of oral and pharyngeal squamous cell carcinoma.Anti-CK10 has demonstrated utility in the differentiation of extra-mammary Paget′s disease (negative) from basal cell carcinoma and squamous cell carcinoma (positive).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
Cytokeratin 10 Positive Control Slides, Product No. 410S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Roland Moll et al.
Histochemistry and cell biology, 129(6), 705-733 (2008-05-08)
The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed
Ichiro Kurokawa et al.
Experimental dermatology, 20(3), 217-228 (2011-02-18)
Keratins are a highly diverse family of cytoskeletal proteins and important markers of epithelial cell differentiation. In this review, applying the new keratin nomenclature recently introduced, we summarize and discuss the distribution and significance of keratin patterns in cutaneous epithelial
Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors.
R Moll
Sub-cellular biochemistry, 31, 205-262 (1999-02-05)
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