生物来源
rabbit
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
EP97, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
表单
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (410R-14)
vial of 0.5 mL concentrate (410R-15)
bottle of 1.0 mL predilute (410R-17)
vial of 1.0 mL concentrate (410R-16)
bottle of 7.0 mL predilute (410R-18)
制造商/商品名称
Cell Marque®
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同位素/亚型
IgG
控制
squamous cell carcinoma
运输
wet ice
储存温度
2-8°C
可视化
cytoplasmic
基因信息
human ... KRT10(3858)
一般描述
Cytokeratin 10 (CK10) belongs to type I and acidic keratin family. It is low molecular weight keratin that is usually expressed in suprabasal keratinocytes and can also be seen in suprabasal cells of internal noncornifying, stratified squamous epithelia.In addition, CK10 is reported to be a typical component of cells of eccrine sweat gland ducts and sebaceous cells.Anti-CK10 is helpful in the identification of well differentiated squamous cell carcinoma derived from skin or from internal organs.However, CK10 was found to be sparse in poorly differentiated squamous cell carcinoma, even though it has been reported that focal CK10 expression has been found in 50% of cases of oral and pharyngeal squamous cell carcinoma.Anti-CK10 has demonstrated utility in the differentiation of extra-mammary Paget′s disease (negative) from basal cell carcinoma and squamous cell carcinoma (positive).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
分析说明
 IVD |  IVD |  IVD |  RUO |
其他说明
Cytokeratin 10 Positive Control Slides, Product No. 410S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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法规信息
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此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ichiro Kurokawa et al.
Experimental dermatology, 20(3), 217-228 (2011-02-18)
Keratins are a highly diverse family of cytoskeletal proteins and important markers of epithelial cell differentiation. In this review, applying the new keratin nomenclature recently introduced, we summarize and discuss the distribution and significance of keratin patterns in cutaneous epithelial
Roland Moll et al.
Histochemistry and cell biology, 129(6), 705-733 (2008-05-08)
The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed
Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors.
R Moll
Sub-cellular biochemistry, 31, 205-262 (1999-02-05)
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