41111
阿吗碱
≥98.0% (HPLC)
别名:
δ-育亨宾碱, 四氢蛇根碱, 萝巴新
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关于此项目
经验公式（希尔记法）:
C21H24N2O3
化学文摘社编号:
分子量:
352.43
MDL number:
UNSPSC Code:
12352200
EC Number:
207-589-5
NACRES:
NA.25
Beilstein/REAXYS Number:
97268
SMILES string
N21[C@@H](C[C@H]5[C@@H]([C@@H](OC=C5C(=O)OC)C)C2)c3[nH]c4c(c3CC1)cccc4
InChI
1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1
InChI key
GRTOGORTSDXSFK-XJTZBENFSA-N
assay
≥98.0% (HPLC)
optical activity
[α]/D -65±3°, c = 1 in chloroform
mp
~258 °C (dec.)
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
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Application
Ajmalicine (δ-Yohimbine, Py-Tetrahydroserpentine, Raubasine) is an alkaloid used to study its effects as an antagonist of adrenergic and nicotinic receptors.
Biochem/physiol Actions
Metabolite in the indole alkaloid biosynthesis (serpentine production); found naturally in various plants such as Rauwolfia spp., Catharanthus roseus, and Mitragyna speciosa. It shows antimicrobial activity, and is used as an anti-hypertensive and sedative.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
David M Pereira et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 17(8-9), 646-652 (2009-12-08)
The leaves of Catharanthus roseus constitute the only source of the well known indolomonoterpenic alkaloids vincristine and vinblastine. In this work we studied the biological potential of the roots, which are used in several countries as decocts or hot water
Roberts, M. F.
Alkaloids: biochemistry, ecology, and medicinal applications, 450-450 (1998)
W G Kurz et al.
Planta medica, 42(1), 22-31 (1981-05-01)
A cell line of Catharanthus roseus (L.) G. Don coded PRL # 200, was characterized with respect to its biosynthetic capabilities for indolealkaloids, in particular catharanthine, in suspension cultures. Other alkaloids isolated are vallesiachotamine isomers, ajmalicine, hörhammericine, hörhammerinine, vindolinine, 19-epivindolinine
P Demichel et al.
British journal of pharmacology, 83(2), 505-510 (1984-10-01)
The actions of raubasine, tetrahydroalstonine and akuammigine were studied on pre- and postsynaptic alpha-adrenoceptors of the rat vas deferens. These three drugs competitively antagonized the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 6.57, 4.56 and 4.68 respectively.
Francisco León et al.
Natural product communications, 4(7), 907-910 (2009-09-08)
Mitragyna speciosa (Rubiaceae) has traditionally been used in the tropical regions of Asia, Africa and Indonesia as a substitute for opium. Indole alkaloids are the most common compounds that have been isolated. We investigated the constituents of the leaves of
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