41405
(R)-3-Methyl-2-oxovaleric acid lithium salt hydrate
≥95.0% (TLC)
别名:
(R)-3-Methyl-2-oxopentanoic acid lithium salt, (R)-Ketoisoleucine lithium salt, Lithium (R)-3-methyl-2-oxovalerate
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关于此项目
经验公式（希尔记法）:
C6H9LiO3 · xH2O
分子量:
136.07 (anhydrous basis)
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.25
MDL number:
产品名称
(R)-3-Methyl-2-oxovaleric acid lithium salt hydrate, ≥95.0% (TLC)
SMILES string
[Li+].O.CC[C@@H](C)C(=O)C([O-])=O
InChI key
PTRNELNRMVEQEC-RZFWHQLPSA-M
InChI
1S/C6H10O3.Li.H2O/c1-3-4(2)5(7)6(8)9;;/h4H,3H2,1-2H3,(H,8,9);;1H2/q;+1;/p-1/t4-;;/m1../s1
assay
≥95.0% (TLC)
form
powder or crystals
optical activity
[α]/D -18.0±2.0°, c = 0.1 in hydrochloric acid
composition
carbon content, 52.96% (theory, anhydrous basis), hydrogen content, 6.67% (theory, anhydrous basis)
color
white to off-white
storage temp.
2-8°C
Biochem/physiol Actions
3-Methyl-2-oxovaleric acid is a metabolite of isoleucine in human, animals and bacteria. Used as a clinical marker for maple syrup urine disease (MSUD).
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Analytical approach in diagnosis of inherited metabolic diseases. Maple syrup urine disease (MSUD). Simultaneous analysis of metabolites in urine by enantioselective multidimensional capillary gas chromatography-mass spectrometry (enantio-MDGC-MS).
Podebrad, F., et al.
Journal of High Resolution Chromatography, 20, 355-362 (1997)
U Wendel et al.
Clinica chimica acta; international journal of clinical chemistry, 208(1-2), 85-91 (1992-06-15)
An enzymatic method for the separate measurement of both chiral 2-oxo-3-methylvaleric acid (OMV) compounds, (S)- and (R)-OMV, by NADH-dependent enantioselective amination using leucine dehydrogenase in the presence of a NADH regenerating system is described. This method allows the quantitative determination
Analytical approach in diagnosis of inherited metabolic diseases: Maple Syrup Urine Disease (MSUD).
Podebrad, F., et al.
GIT, 3, 15-16 (1999)
P Schadewaldt et al.
Journal of chromatography. B, Biomedical applications, 682(2), 209-218 (1996-07-12)
A sensitive method for the determination of S- and R-3-methyl-2-oxopentanoate enantiomers (KMV, alpha-keto-beta-methylvalerate) in physiological fluids suitable for isotope enrichment analysis is described: after extraction with acid, 2-oxo acids are separated from interfering amino acids by cation-exchange chromatography. Reductive amination
Synthesis and gas chromatography/mass spectrometry analysis of stereoisomers of 2-hydroxy-3-methylpentanoic acid.
O A Mamer
Methods in enzymology, 324, 3-10 (2000-09-16)
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