41405
(R)-3-Methyl-2-oxovaleric acid lithium salt hydrate
≥95.0% (TLC)
别名:
(R)-3-Methyl-2-oxopentanoic acid lithium salt, (R)-Ketoisoleucine lithium salt, Lithium (R)-3-methyl-2-oxovalerate
产品名称
(R)-3-Methyl-2-oxovaleric acid lithium salt hydrate, ≥95.0% (TLC)
方案
≥95.0% (TLC)
表单
powder or crystals
旋光性
[α]/D -18.0±2.0°, c = 0.1 in hydrochloric acid
组成
carbon content, 52.96% (theory, anhydrous basis)
hydrogen content, 6.67% (theory, anhydrous basis)
颜色
white to off-white
储存温度
2-8°C
SMILES字符串
[Li+].O.CC[C@@H](C)C(=O)C([O-])=O
InChI
1S/C6H10O3.Li.H2O/c1-3-4(2)5(7)6(8)9;;/h4H,3H2,1-2H3,(H,8,9);;1H2/q;+1;/p-1/t4-;;/m1../s1
InChI key
PTRNELNRMVEQEC-RZFWHQLPSA-M
生化/生理作用
3-Methyl-2-oxovaleric acid is a metabolite of isoleucine in human, animals and bacteria. Used as a clinical marker for maple syrup urine disease (MSUD).
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
P Schadewaldt et al.
Journal of chromatography. B, Biomedical applications, 682(2), 209-218 (1996-07-12)
A sensitive method for the determination of S- and R-3-methyl-2-oxopentanoate enantiomers (KMV, alpha-keto-beta-methylvalerate) in physiological fluids suitable for isotope enrichment analysis is described: after extraction with acid, 2-oxo acids are separated from interfering amino acids by cation-exchange chromatography. Reductive amination
Analytical approach in diagnosis of inherited metabolic diseases: Maple Syrup Urine Disease (MSUD).
Podebrad, F., et al.
GIT, 3, 15-16 (1999)
U Wendel et al.
Clinica chimica acta; international journal of clinical chemistry, 208(1-2), 85-91 (1992-06-15)
An enzymatic method for the separate measurement of both chiral 2-oxo-3-methylvaleric acid (OMV) compounds, (S)- and (R)-OMV, by NADH-dependent enantioselective amination using leucine dehydrogenase in the presence of a NADH regenerating system is described. This method allows the quantitative determination
Analytical approach in diagnosis of inherited metabolic diseases. Maple syrup urine disease (MSUD). Simultaneous analysis of metabolites in urine by enantioselective multidimensional capillary gas chromatography-mass spectrometry (enantio-MDGC-MS).
Podebrad, F., et al.
Journal of High Resolution Chromatography, 20, 355-362 (1997)
Synthesis and gas chromatography/mass spectrometry analysis of stereoisomers of 2-hydroxy-3-methylpentanoic acid.
O A Mamer
Methods in enzymology, 324, 3-10 (2000-09-16)
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