41405
(R)-3-Methyl-2-oxovaleric acid lithium salt hydrate
≥95.0% (TLC)
别名:
(R)-3-Methyl-2-oxopentanoic acid lithium salt, (R)-Ketoisoleucine lithium salt, Lithium (R)-3-methyl-2-oxovalerate
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关于此项目
经验公式（希尔记法）:
C6H9LiO3 · xH2O
分子量:
136.07 (anhydrous basis)
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.25
MDL number:
产品名称
(R)-3-Methyl-2-oxovaleric acid lithium salt hydrate, ≥95.0% (TLC)
SMILES string
[Li+].O.CC[C@@H](C)C(=O)C([O-])=O
InChI key
PTRNELNRMVEQEC-RZFWHQLPSA-M
InChI
1S/C6H10O3.Li.H2O/c1-3-4(2)5(7)6(8)9;;/h4H,3H2,1-2H3,(H,8,9);;1H2/q;+1;/p-1/t4-;;/m1../s1
assay
≥95.0% (TLC)
form
powder or crystals
optical activity
[α]/D -18.0±2.0°, c = 0.1 in hydrochloric acid
composition
carbon content, 52.96% (theory, anhydrous basis), hydrogen content, 6.67% (theory, anhydrous basis)
color
white to off-white
storage temp.
2-8°C
Biochem/physiol Actions
3-Methyl-2-oxovaleric acid is a metabolite of isoleucine in human, animals and bacteria. Used as a clinical marker for maple syrup urine disease (MSUD).
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
P Schadewaldt et al.
Journal of chromatography. B, Biomedical applications, 682(2), 209-218 (1996-07-12)
A sensitive method for the determination of S- and R-3-methyl-2-oxopentanoate enantiomers (KMV, alpha-keto-beta-methylvalerate) in physiological fluids suitable for isotope enrichment analysis is described: after extraction with acid, 2-oxo acids are separated from interfering amino acids by cation-exchange chromatography. Reductive amination
Analytical approach in diagnosis of inherited metabolic diseases: Maple Syrup Urine Disease (MSUD).
Podebrad, F., et al.
GIT, 3, 15-16 (1999)
U Wendel et al.
Clinica chimica acta; international journal of clinical chemistry, 208(1-2), 85-91 (1992-06-15)
An enzymatic method for the separate measurement of both chiral 2-oxo-3-methylvaleric acid (OMV) compounds, (S)- and (R)-OMV, by NADH-dependent enantioselective amination using leucine dehydrogenase in the presence of a NADH regenerating system is described. This method allows the quantitative determination
Analytical approach in diagnosis of inherited metabolic diseases. Maple syrup urine disease (MSUD). Simultaneous analysis of metabolites in urine by enantioselective multidimensional capillary gas chromatography-mass spectrometry (enantio-MDGC-MS).
Podebrad, F., et al.
Journal of High Resolution Chromatography, 20, 355-362 (1997)
Synthesis and gas chromatography/mass spectrometry analysis of stereoisomers of 2-hydroxy-3-methylpentanoic acid.
O A Mamer
Methods in enzymology, 324, 3-10 (2000-09-16)
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