41593
2-Ethoxy-2-(2-naphthyl)acetonitrile
≥95.0% (HPLC)
别名:
α-Ethoxy-2-naphthaleneacetonitrile
方案
≥95.0% (HPLC)
荧光
λex 227 nm; λem 336 nm in methanol
SMILES字符串
CCOC(C#N)c1ccc2ccccc2c1
InChI
1S/C14H13NO/c1-2-16-14(10-15)13-8-7-11-5-3-4-6-12(11)9-13/h3-9,14H,2H2,1H3
InChI key
SERAXWXRCADJHK-UHFFFAOYSA-N
应用
2-Ethoxy-2-(2-naphthyl)acetonitrile is a fluorogenic substrate for use in cytochrome P450 assays.
Alexander Zawaira et al.
Pharmacogenetics and genomics, 18(6), 467-476 (2008-05-23)
We have used maximum-likelihood models of codon substitution to investigate the role of adaptive evolution in the evolution of cytochrome P450 (CYP) sequences. Evidence for the operation of adaptive evolution in the evolution of rat CYP2C, rabbit CYP2C, rat CYP2D
Alexander Zawaira et al.
Current drug metabolism, 12(7), 684-700 (2011-07-12)
The original map of mammalian cytochrome P450 (CYP450) residues involved in substrate recognition was prepared for the CYP2 family by Gotoh in 1992 by manual alignment of mammalian CYP450 residues with substrate recognition site (SRS) residues manually delimited from a
David S Wishart
Drugs in R&D, 8(6), 349-362 (2007-10-30)
Drug development is an intrinsically risky business. Like a high stakes poker game the entry costs are high and the probability of winning is low. Indeed, only a tiny percentage of lead compounds ever reach US FDA approval. At any
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