GATA1 (4F5) Mouse Monoclonal Antibody

GATA-1 is a nuclear transcription factor that belongs to the family of GATA proteins which bind the DNA sequence (A/T)GATA-(A/G) by a highly conserved zinc finger domain located on the X chromosome.^1,2 GATA1 is expressed in the cells of the erythroid, megakaryocytic and mast cell lineages and is found in low levels in multipotential and Sertoli cells of the testis.¹ GATA1 normally suppresses the proliferation of megakaryocytic and erythroid precursors while promoting their differentiation. GATA-1 is crucial for normal erythroid and megakaryocytic development. Missense mutations in GATA1 in humans causes a familial dyserythropoietic anemia and thrombocytopenia. GATA1 has been implicated in childhood acute megakaryoblastic leukemia (AMKL) and transient myeloproliferative disorder in children with Down syndrome (DS). Acquired mutations in exon 2 of GATA1 an X-linked gene has been described in DS patients with AMKL.² Anti-GATA1 can be used to identify megakaryocytes, erythroid precursors and megakaryocytic malignancies.^{1, 2}

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

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GATA1 Positive Control Slides, Product No. 417S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

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