biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
2A10C2, monoclonal
description
(For In Vitro Diagnostic Use in Select Regions (See Chart))
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (423M-14), vial of 0.5 mL concentrate (423M-15), bottle of 1.0 mL predilute (423M-17), vial of 1.0 mL concentrate (423M-16), bottle of 7.0 mL predilute (423M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG1
control
leiomyoma
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... TAGLN(6876)
General description
Transgelin is a shape change sensitive 22-25 kDa actin cross-linking/gelling protein of the calponin family localized to the cell membrane and cytoplasm as a novel regulator of MMP-9 expression.1 Recent evidence suggests that transgelin may act as a tumor suppressor; for example, expression can be lost in prostate, breast and colon cancers which is consistent with suppression of the metallo matrix protease-9 (MMP-9) by transgelin, whereas MMP-9 is upregulated in these common cancers.1 This protein is ubiquitous to vascular and visceral smooth muscle and is considered an early marker of smooth muscle differentiation and may be an early and sensitive marker for the onset of transformation.2 Transgelin can be found in fibroblasts, smooth muscle and some epithelium where expression is likely driven by TGF-beta1. 3 In some cases differentiating smooth muscle within malignant lesions can be challenging, therefore use of myogenic markers such as transgelin may serve to define smooth muscle differentiation in soft tissue tumors.1-3
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Transgelin Positive Control Slides, Product No. 423S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
未找到合适的产品？
试试我们的产品选型工具.
法规信息
监管及禁止进口产品
此项目有
Yves-Marie Robin et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(4), 502-510 (2012-11-24)
Immunohistochemical use of myogenic markers serves to define smooth or skeletal muscle differentiation in soft tissue tumors. Establishing smooth muscle differentiation in malignant lesions can be challenging in some cases. We immunohistochemically examined 900 soft tissue tumors selected from the
Stephen J Assinder et al.
The international journal of biochemistry & cell biology, 41(3), 482-486 (2008-04-02)
Transgelin is a shape change sensitive 22 kDa actin-binding protein of the calponin family. It contains a C-terminal calponin-like module (CLIK(23)) and an upstream positively charged amino acid region required for actin binding. Transgelin is ubiquitous to vascular and visceral
Gaëlle Pérot et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(6), 840-850 (2013-11-30)
The clinical relevance of accurately diagnosing pleomorphic sarcomas has been shown, especially in cases of undifferentiated pleomorphic sarcomas with myogenic differentiation, which appear significantly more aggressive. To establish a new smooth muscle differentiation classification and to test its prognostic value
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持