生物来源
microbial
方案
≥90% (TLC)
表单
powder
脂质类型
sphingolipids
储存温度
−20°C
生化/生理作用
双唾液酸神经节苷脂GD3在造血细胞中CD95和神经酰胺诱导的凋亡以及肝细胞和结肠细胞中TNF-α-诱导的凋亡中起重要作用，因此充当细胞死亡效应物。
其他说明
恶性黑色素瘤中的肿瘤特异性抗原。GD3的抗体可诱导动物和人类肿瘤生长的部分缓解
销售限制可能适用
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
个人防护装备
Eyeshields, Gloves, type N95 (US)
P Hersey et al.
Cancer immunology, immunotherapy : CII, 24(2), 144-150 (1987-01-01)
Previous studies have shown that monoclonal antibodies (M.Ab) to the ganglioside GD3 may induce partial remissions in tumour growth in patients with melanoma. In vitro studies demonstrated that M.Abs to GD3 may also enhance lymphocyte responses to phytohemagglutinin and interleukin
Carmen García-Ruiz et al.
The Journal of biological chemistry, 277(39), 36443-36448 (2002-07-16)
The interaction of mitochondria with proapoptotic proteins activates apoptosis pathways. Previous findings have identified ganglioside GD3 (GD3) as an emerging apoptotic lipid intermediate that targets mitochondria in response to death signals. Using immunoelectron and laser scanning confocal microscopy, we characterize
Anna Colell et al.
FEBS letters, 526(1-3), 135-141 (2002-09-05)
In the present study we assessed the contribution of acidic sphingomyelinase (ASMase), a ceramide generating enzyme, in tumor necrosis factor (TNF)-mediated apoptosis in human colon HT-29 cells. TNF induced apoptosis in HT-29 cells in a time- and dose-dependent fashion. Downregulation
R De Maria et al.
Science (New York, N.Y.), 277(5332), 1652-1655 (1997-09-12)
Gangliosides participate in development and tissue differentiation. Cross-linking of the apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor cells triggered GD3 ganglioside synthesis and transient accumulation. CD95-induced GD3 accumulation depended on integral receptor "death domains"
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