44270
反式，反式-法尼基焦磷酸 铵盐
≥95.0% (HPLC)
别名:
法尼基二磷酸酯 铵盐, （E,E）-3,7,11-三甲基-2,6,10-十二碳三烯-1-基焦磷酸盐 铵盐
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关于此项目
经验公式（希尔记法）:
C15H28O7P2 · xNH3
分子量:
382.33 (free acid basis)
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352212
Beilstein/REAXYS Number:
2482197
Assay:
≥95.0% (HPLC)
Form:
solid
产品名称
反式，反式-法尼基焦磷酸 铵盐, ≥95.0% (HPLC)
InChI key
CPYJTMLHKIWGDF-NDHHSALASA-N
SMILES string
N.C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
InChI
1S/C15H28O7P2.H3N/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18;/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18);1H3/b14-9+,15-11+;
assay
≥95.0% (HPLC)
form
solid
storage temp.
−20°C
Quality Level
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相关类别
Application
法尼基二磷酸铵盐可用于研究称为法呢基化的翻译后过程，其用于修饰重要蛋白质，例如Ras癌基因。
Biochem/physiol Actions
法尼基焦磷酸盐是更复杂的倍半萜类化合物、萜类化合物和类固醇的生物合成中的关键中间体，并且 FPP 和相应的醇法尼醇具有不同生物学功能。FPP 在 Ras 蛋白的翻译后加工中起重要作用。Ras 的突变形式与人类癌症相关，因此在癌症研究中进行了研究。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
S M Sebti et al.
Oncogene, 19(56), 6584-6593 (2001-06-28)
In 1990, more than 10 years after the discovery that the low molecular weight GTPase Ras is a major contributor to human cancer, farnesylation, a lipid posttranslational modification required for the cancer-causing activity of Ras, emerged as a major target
Farnesyl Diphosphate Analogues with Aryl Moieties Are Efficient Alternate Substrates for Protein Farnesyltransferase.
Subramanian T, Pais JE, Liu S, et al.
Biochemistry (2012)
Po-Huang Liang et al.
European journal of biochemistry, 269(14), 3339-3354 (2002-07-24)
In this review, we summarize recent progress in studying three main classes of prenyltransferases: (a) isoprenyl pyrophosphate synthases (IPPSs), which catalyze chain elongation of allylic pyrophosphate substrates via consecutive condensation reactions with isopentenyl pyrophosphate (IPP) to generate linear polymers with
H Xie et al.
The Journal of organic chemistry, 65(25), 8552-8563 (2000-12-12)
The a-factor of Saccharomyces cerevisiae is a dodecapeptide pheromone (YIIKGVFWDPAC(Farnesyl)-OCH(3), 1), in which post-translational modification with a farnesyl isoprenoid and carboxymethyl group is required for full biological activity. This peptide has been used as a model system to explore the
R J Hohl et al.
Lipids, 33(1), 39-46 (1998-02-21)
This investigation compares the effects of three farnesyl pyrophosphate analogs on selected aspects of isoprenoid metabolism. E,E-alpha-Hydroxyfarnesylphosphonate was prepared by an improved variation on a literature synthesis, which also gave access to the new Z,E-alpha-hydroxyfarnesyl- and alpha-hydroxygeranylphosphonates. A striking find
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