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Merck
CN

460R-1

Sigma-Aldrich

Heat Shock Protein 70 (EP377) Rabbit Monoclonal Primary Antibody

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UNSPSC代码:
12352203

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生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP377, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (460R-14)
vial of 0.1 mL concentrate Research Use Only (460R-14-RUO)
vial of 0.5 mL concentrate (460R-15)
vial of 1.0 mL concentrate (460R-16)
vial of 1.0 mL concentrate Research Use Only (460R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (460R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (460R-17)
vial of 7.0 mL pre-dilute ready-to-use (460R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (460R-18-RUO)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

hepatocellular carcinoma

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic, nuclear

基因信息

human ... HSPA1A(3303)

相关类别

一般描述

The Heat Shock Protein 70 family of highly conserved chaperone proteins increase in expression upon exposure to stress factors such as temperature shock, hypoxia, oxidative stress, and pH change. This promotes cell survival by repairing misfolded proteins and preventing protein aggregates, among other functions. Likewise, tumor cells can use this mechanism to confer a survival advantage as demonstrated in Heat Shock Protein 70 overexpression in hepatocellular carcinoma.

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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分析说明

United States - IVD
European Union - IVD
Japan - RUO

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000456146
0000456146
0000449497
0000449497
0000418439

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Stephen M Lagana et al.
Applied immunohistochemistry & molecular morphology : AIMM, 21(2), 170-176 (2012-08-24)
The pathologic distinction between hepatocellular carcinoma (HCC) and hepatocellular adenoma (HCA) is sometimes problematic due to histologic overlap between the 2 entities, a problem amplified on small biopsy specimens. Several recently characterized immunohistochemical markers such as glypican-3 (GPC-3), heat-shock protein-70
Luca Di Tommaso et al.
Journal of hepatology, 50(4), 746-754 (2009-02-24)
Liver biopsy for hepatocellular carcinoma (HCC) detection is largely restricted to small hepatocellular lesions, which are often morphologically challenging, requiring careful distinction between dysplastic nodules (high-grade) and well-differentiated HCC. We investigated the diagnostic accuracy of a panel of markers (HSP70
Eun Shin et al.
Journal of hepato-biliary-pancreatic sciences, 18(4), 544-550 (2011-01-15)
Heat shock protein 70 (HSP70) and glutamine synthetase (GS) have been proposed to be promising markers for the differentiation of malignant and benign hepatocellular lesions. The aim of this study was to investigate the clinicopathological significance of the expression of
Maureen E Murphy
Carcinogenesis, 34(6), 1181-1188 (2013-04-09)
The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent
Thuy B Nguyen et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 29(3), 283-292 (2016-01-16)
Well-differentiated hepatocellular carcinoma can mimic high-grade dysplastic nodule in cirrhotic liver and hepatocellular adenoma in non-cirrhotic liver. This study evaluates the efficacy of combined use of heat-shock protein 70 (HSP70), glutamine synthetase (GS) and glypican-3 in this setting. Immunohistochemistry for

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