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Merck
CN

460R-1

Heat Shock Protein 70 (EP377) Rabbit Monoclonal Primary Antibody

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关于此项目

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EP377, monoclonal
Application:
IHC (p)
Citations:
5

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP377, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (460R-14), vial of 0.1 mL concentrate Research Use Only (460R-14-RUO), vial of 0.5 mL concentrate (460R-15), vial of 1.0 mL concentrate (460R-16), vial of 1.0 mL concentrate Research Use Only (460R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (460R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (460R-17), vial of 7.0 mL pre-dilute ready-to-use (460R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (460R-18-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

hepatocellular carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, nuclear

Quality Level

100, 500

Gene Information

human ... HSPA1A(3303)

相关类别

General description

The Heat Shock Protein 70 family of highly conserved chaperone proteins increase in expression upon exposure to stress factors such as temperature shock, hypoxia, oxidative stress, and pH change. This promotes cell survival by repairing misfolded proteins and preventing protein aggregates, among other functions. Likewise, tumor cells can use this mechanism to confer a survival advantage as demonstrated in Heat Shock Protein 70 overexpression in hepatocellular carcinoma.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000456146
0000456146
0000449497
0000449497
0000418439

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Stephen M Lagana et al.
Applied immunohistochemistry & molecular morphology : AIMM, 21(2), 170-176 (2012-08-24)
The pathologic distinction between hepatocellular carcinoma (HCC) and hepatocellular adenoma (HCA) is sometimes problematic due to histologic overlap between the 2 entities, a problem amplified on small biopsy specimens. Several recently characterized immunohistochemical markers such as glypican-3 (GPC-3), heat-shock protein-70
Luca Di Tommaso et al.
Journal of hepatology, 50(4), 746-754 (2009-02-24)
Liver biopsy for hepatocellular carcinoma (HCC) detection is largely restricted to small hepatocellular lesions, which are often morphologically challenging, requiring careful distinction between dysplastic nodules (high-grade) and well-differentiated HCC. We investigated the diagnostic accuracy of a panel of markers (HSP70
Maureen E Murphy
Carcinogenesis, 34(6), 1181-1188 (2013-04-09)
The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent
Eun Shin et al.
Journal of hepato-biliary-pancreatic sciences, 18(4), 544-550 (2011-01-15)
Heat shock protein 70 (HSP70) and glutamine synthetase (GS) have been proposed to be promising markers for the differentiation of malignant and benign hepatocellular lesions. The aim of this study was to investigate the clinicopathological significance of the expression of
Thuy B Nguyen et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 29(3), 283-292 (2016-01-16)
Well-differentiated hepatocellular carcinoma can mimic high-grade dysplastic nodule in cirrhotic liver and hepatocellular adenoma in non-cirrhotic liver. This study evaluates the efficacy of combined use of heat-shock protein 70 (HSP70), glutamine synthetase (GS) and glypican-3 in this setting. Immunohistochemistry for

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