51455
维生素 K3 2,3-环氧
≥98.5% (HPLC)
别名:
1a，7a-二氢-1a-甲基萘[2，3-b] 环氧乙烯-2，7-二酮, 2-甲基-1，4-萘醌环氧化物, 2，3-环氧-2，3-二氢-2-甲基-1，4-萘醌, 甲萘醌2，3-环氧化物, 神经干细胞 65669
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关于此项目
经验公式（希尔记法）:
C11H8O3
化学文摘社编号:
分子量:
188.18
Beilstein:
144630
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
≥98.5% (HPLC)
表单
powder
颜色
white
适用性
complies for H-NMR
应用
cell analysis
储存温度
−20°C
SMILES字符串
O=C1C2(C)C(O2)C(C3=CC=CC=C31)=O
InChI
1S/C11H8O3/c1-11-9(13)7-5-3-2-4-6(7)8(12)10(11)14-11/h2-5,10H,1H3
InChI key
NNUKDUBCRRYXDC-UHFFFAOYSA-N
生化/生理作用
维生素K代谢的代谢产物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Toru Kitano et al.
Biological & pharmaceutical bulletin, 35(4), 617-623 (2012-04-03)
We investigated the cytotoxicity of eight vitamin K3 (VK3) analogs against neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, and SK-N-SH) and normal cell lines (human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)) using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay.
Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones.
Dharmaraja, A.T., et al
MedChemComm, 3, 219-224 (2012)
The Active Site of Vitamin K and the Role of the Vitamin K-Dependent Carboxylase.
Naganathan, S., et al.
Journal of the American Chemical Society, 116, 9831-9839 (1994)
Nan Chen et al.
Organic letters, 10(3), 381-384 (2008-01-11)
An efficient three-step construction of the highly oxygenated D-ring of the kinamycin antibiotics is reported for a simple model system. A comparison of the spectroscopic characteristics of the synthetic models with those of natural kinamycin F, which is suspected to
Xiao Lu et al.
ACS medicinal chemistry letters, 3(12), 1029-1033 (2012-12-13)
Cations of hydroxy-substituted 1,4-naphthoquinones were synthesized and evaluated as antiplasmodial agents against Plasmodium falciparum. The atovaquone analogues were found to be inactive as antagonists of parasite growth, which was attributed to ionization of the acidic hydroxyl moiety. Upon modification to
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