51947
N-Acetyl-D-galactosamin-6-sulfat 钠盐
≥98.0% (TLC)
别名:
GalNAc-6S
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关于此项目
线性分子式:
C8H14O9NSNa
化学文摘社编号:
分子量:
323.25
UNSPSC Code:
12352201
PubChem Substance ID:
MDL number:
InChI
1S/C8H15NO9S.Na/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16;/h4-8,11-13H,2H2,1H3,(H,9,10)(H,14,15,16);/q;+1/p-1/t4-,5-,6+,7-,8?;/m1./s1
SMILES string
[Na+].CC(=O)N[C@H]1C(O)O[C@H](COS([O-])(=O)=O)[C@H](O)[C@@H]1O
InChI key
CBUJZKTVEFVBBG-DBKUKYHUSA-M
biological source
bovine (Ruminant- Cow, Ox, Buffalo)
description
Mixed anomers
assay
≥98.0% (TLC)
form
solid
optical activity
[α]/D 54.0±4.0, c = 0.1% (w/v) in water
technique(s)
thin layer chromatography (TLC): suitable
storage temp.
−20°C
Quality Level
Application
N-Acetyl-D-galactosamine 6-sulfate (GalNAc-6S) is used as a substrate to identify, differentiate and characterize N-acetylgalactosamine sulfatase(s). GalNAc-6S is used to study the rare autosomal recessive disorder Mucopolysaccharidosis IVA (MPS IVA).
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
S Tomatsu et al.
Current pharmaceutical biotechnology, 12(6), 931-945 (2011-04-22)
Mucopolysaccharidosis IVA (MPS IVA), also known as Morquio A, is a rare, autosomal recessive disorder caused by a deficiency of the lysosomal enzyme N-acetylgalatosamine-6-sulfate-sulfatase (GALNS), which catalyzes a step in the catabolism of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate
G J Gibson et al.
The Biochemical journal, 248(3), 755-764 (1987-12-15)
Initial purification of N-acetylgalactosamine-4-sulphate sulphatase from human liver homogenates containing approx. 1 mg of enzyme in 26 g of soluble proteins was achieved by a six-column chromatography procedure and yielded approx. 40 micrograms of a single major protein species. Enzyme
Souhir Khedhiri et al.
Diagnostic pathology, 6, 11-11 (2011-01-22)
Mucopolysaccharidosis type IVA or Morquio A syndrome is characterized by the lack of N-acetylgalactosamine-6-sulfate-sulfatase and the accumulation of keratan sulfate and chondroitin-6-sulfate in the lysosomes. At least, 148 mutations and 16 polymorphisms were identified in the GALNS gene.The aim of
Václav Profant et al.
Physical chemistry chemical physics : PCCP, 21(14), 7367-7377 (2019-03-23)
Glycosaminoglycans are linear carbohydrate polymers with essential roles in many biological processes. Chondroitin sulfate (CS) is one of them, omnipresent in living organisms as an important structural component of cartilage. It provides much of its resistance to compression. Despite its
M Masue et al.
Journal of biochemistry, 110(6), 965-970 (1991-12-01)
N-Acetylgalactosamine-6-sulfate sulfatase from human placenta was purified 33,600-fold using beta-N-acetyl-D-galactosamine 6-sulfate-(1----4)-beta-D-glucuronic acid-(1----3)-N-acetyl-D-[3H]galactosaminitol 6-sulfate as the substrate. This enzyme is an oligomer with a molecular mass of 120 kDa and consists of polypeptides of 40 and 15 kDa. The 15 kDa
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