54274
白屈菜碱
≥97.0% (HPLC)
别名:
Stylophorin
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关于此项目
经验公式（希尔记法）:
C20H19NO5
化学文摘社编号:
分子量:
353.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
207-504-1
MDL number:
产品名称
白屈菜碱, ≥97.0% (HPLC)
InChI key
GHKISGDRQRSCII-ZOCIIQOWSA-N
InChI
1S/C20H19NO5/c1-21-7-13-11(2-3-15-20(13)26-9-23-15)18-14(22)4-10-5-16-17(25-8-24-16)6-12(10)19(18)21/h2-3,5-6,14,18-19,22H,4,7-9H2,1H3/t14-,18-,19+/m0/s1
SMILES string
[H][C@]12[C@@H](O)Cc3cc4OCOc4cc3[C@@]1([H])N(C)Cc5c6OCOc6ccc25
assay
≥97.0% (HPLC)
form
solid
impurities
~5% water
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
Inhibits tubulin polymerisation (IC50=24 μM), thereby disrupting microtubule structure in cells and inducing a G2/M mitotic arrest.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Z Kleinrok et al.
Polish journal of pharmacology and pharmacy, 42(5), 417-424 (1990-09-01)
Chelidonine administered to rats in doses of 25, 50, 100 and 200 mg/kg ip exerted an inhibitory effect on the dopaminergic structures in the rat. It was shown that chelidonine decreased amphetamine- and apomorphine-induced hyperactivity and inhibited amphetamine and apomorphine
Matthew J Fleming et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 14(7), 2112-2124 (2008-01-18)
New enantioselective syntheses of the B/C hexahydrobenzo[c]phenanthridine alkaloids (+)-homochelidonine, (+)-chelamidine, (+)-chelidonine, (+)-chelamine, and (+)-norchelidonine are described. Our rapid and convergent route to this class of natural products involved the development and application of a Pd II-catalyzed asymmetric ring-opening reaction of
Zhi-Xiong Ma et al.
Organic letters, 14(11), 2742-2745 (2012-05-12)
Total syntheses of chelidonine and norchelidonine featuring an enamide-benzyne-[2 + 2] cycloaddition initiated cascade is described. The cascade includes a pericyclic ring-opening and intramolecular Diels-Alder reaction.
Maria Emilia Isolani et al.
European journal of pharmacology, 686(1-3), 1-7 (2012-04-17)
The presence of adult pluripotent stem cells and the amazing regenerative capabilities make planarian flatworms an extraordinary experimental model to assess in vivo the effects of substances of both natural and synthetic origin on stem cell dynamics. This study focuses
Vitaliy Kaminskyy et al.
Toxicology letters, 177(3), 168-181 (2008-03-08)
Sanguinarine, chelerythrine and chelidonine possess prominent apoptotic effects towards cancer cells. In this study, we found that sanguinarine and chelerythrine induce apoptosis in human CEM T-leukemia cells, and that is accompanied by an early increase in cytosolic cytochrome c that
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