55845
1,2-二硬脂酰- 锡 -甘油-3-磷酸-rac-（1-甘油） 钠盐
≥97.0% (TLC)
别名:
1,2-二硬脂酰- 锡 -甘油-3-磷酸甘油, L-α-磷脂酰-DL-甘油，二硬脂酰, DSPG-Na, PG(18:0/18:0)
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关于此项目
经验公式（希尔记法）:
C42H82NaO10P
化学文摘社编号:
分子量:
801.06
MDL编号:
UNSPSC代码:
51191904
PubChem化学物质编号:
NACRES:
NA.85
生物来源
synthetic
方案
≥97.0% (TLC)
表单
powder
官能团
ester
脂质类型
phosphoglycerides
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(OCC(O)CO)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Na+]
InChI
1S/C42H83O10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-41(45)49-37-40(38-51-53(47,48)50-36-39(44)35-43)52-42(46)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h39-40,43-44H,3-38H2,1-2H3,(H,47,48);/q;+1/p-1/t39?,40-;/m1./s1
InChI key
YNQYZBDRJZVSJE-QTOMIGAPSA-M
生化/生理作用
DSPG 是增强囊性纤维化患者呼吸道黏液清除的最有效磷脂酰甘油。
包装
无底玻璃瓶。内含物装在插入的融合锥内。
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
S Girod de Bentzmann et al.
The European respiratory journal, 6(8), 1156-1161 (1993-09-01)
We have previously shown that a decreased level of phosphatidylglycerol in cystic fibrosis (CF) respiratory mucus is partly responsible for its marked adhesiveness and stickiness, which impair mucus transport, and that distearoyl phosphatidylglycerol (DSPG) was the most efficient form of
Matthias Braun et al.
The Journal of physiology, 559(Pt 2), 397-409 (2004-07-06)
We have investigated the regulation of hormone secretion from rat pancreatic islets by the GABAB receptors (GABABRs). Inclusion of the specific GABABR antagonist CGP 55845 in the extracellular medium increased glucose-stimulated insulin secretion 1.6-fold but did not affect the release
R A Cunha et al.
FEBS letters, 469(2-3), 159-162 (2000-03-14)
Kainate receptors are ionotropic receptors, also reported to couple to G(i)/G(o) proteins, increasing neuronal excitability through disinhibition of neuronal circuits. We directly tested in hippocampal synaptosomes if kainate receptor-mediated inhibition of GABA release involved a metabotropic action. The kainate analogue
Sarah Y Branch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(34), 13861-13872 (2013-08-24)
Restriction of food intake increases the acquisition of drug abuse behavior and enhances the reinforcing efficacy of those drugs. However, the neurophysiological mechanisms responsible for the interactions between feeding state and drug use are largely unknown. Here we show that
Reagan L Pennock et al.
Journal of neurophysiology, 115(5), 2376-2388 (2016-02-26)
Whereas the activation of Gαi/o-coupled receptors commonly results in postsynaptic responses that show acute desensitization, the presynaptic inhibition of transmitter release caused by many Gαi/o-coupled receptors is maintained during agonist exposure. However, an exception has been noted where GABAB receptor
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