55845
1,2-二硬脂酰- 锡 -甘油-3-磷酸-rac-（1-甘油） 钠盐
≥97.0% (TLC)
别名:
1,2-二硬脂酰- 锡 -甘油-3-磷酸甘油, L-α-磷脂酰-DL-甘油，二硬脂酰, DSPG-Na, PG(18:0/18:0)
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关于此项目
经验公式（希尔记法）:
C42H82NaO10P
化学文摘社编号:
分子量:
801.06
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51191904
MDL number:
InChI
1S/C42H83O10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-41(45)49-37-40(38-51-53(47,48)50-36-39(44)35-43)52-42(46)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h39-40,43-44H,3-38H2,1-2H3,(H,47,48);/q;+1/p-1/t39?,40-;/m1./s1
SMILES string
[H][C@@](COP([O-])(OCC(O)CO)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Na+]
InChI key
YNQYZBDRJZVSJE-QTOMIGAPSA-M
biological source
synthetic
assay
≥97.0% (TLC)
form
powder
functional group
ester
lipid type
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
DSPG 是增强囊性纤维化患者呼吸道黏液清除的最有效磷脂酰甘油。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
S Girod de Bentzmann et al.
The European respiratory journal, 6(8), 1156-1161 (1993-09-01)
We have previously shown that a decreased level of phosphatidylglycerol in cystic fibrosis (CF) respiratory mucus is partly responsible for its marked adhesiveness and stickiness, which impair mucus transport, and that distearoyl phosphatidylglycerol (DSPG) was the most efficient form of
Matthias Braun et al.
The Journal of physiology, 559(Pt 2), 397-409 (2004-07-06)
We have investigated the regulation of hormone secretion from rat pancreatic islets by the GABAB receptors (GABABRs). Inclusion of the specific GABABR antagonist CGP 55845 in the extracellular medium increased glucose-stimulated insulin secretion 1.6-fold but did not affect the release
Oksana Lenina et al.
Experimental physiology, 104(7), 1004-1010 (2019-05-11)
What is the central question of this study? Do GABA receptors play any role at the neuromuscular junction? What is the main finding and its importance? In the presence of either ionotropic or metabotropic GABA receptor antagonists, diaphragm muscle force
Reagan L Pennock et al.
Journal of neurophysiology, 115(5), 2376-2388 (2016-02-26)
Whereas the activation of Gαi/o-coupled receptors commonly results in postsynaptic responses that show acute desensitization, the presynaptic inhibition of transmitter release caused by many Gαi/o-coupled receptors is maintained during agonist exposure. However, an exception has been noted where GABAB receptor
R A Cunha et al.
FEBS letters, 469(2-3), 159-162 (2000-03-14)
Kainate receptors are ionotropic receptors, also reported to couple to G(i)/G(o) proteins, increasing neuronal excitability through disinhibition of neuronal circuits. We directly tested in hippocampal synaptosomes if kainate receptor-mediated inhibition of GABA release involved a metabotropic action. The kainate analogue
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