56968
司帕沙星
≥98.0% (HPLC)
别名:
5-氨基-1-环丙基-7-(顺式-3,5-二甲基-1-哌嗪基)-6,8-二氟-1,4-二氢-4-氧代-3-喹啉羧酸
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关于此项目
经验公式（希尔记法）:
C19H22F2N4O3
化学文摘社编号:
分子量:
392.40
UNSPSC Code:
51282944
NACRES:
NA.85
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
9170271
InChI
1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+
SMILES string
C[C@H]1CN(C[C@@H](C)N1)c2c(F)c(N)c3C(=O)C(=CN(C4CC4)c3c2F)C(O)=O
InChI key
DZZWHBIBMUVIIW-DTORHVGOSA-N
biological source
synthetic
assay
≥98.0% (HPLC)
form
powder
color
white to light yellow
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
mode of action
enzyme | inhibits
Gene Information
human ... KCNH1(3756), TOP2A(7153)
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Application
Sparfoxacin is used to study antimicrobial activity against Mycobacteria and respiratory tract infections .
Biochem/physiol Actions
Sparfloxacin fluoroquinolone antibiotic that inhibits bacterial DNA gyrase (topoisomerase II) and/or topoisomerase IV. It inhibits bacterial DNA gyrase-dependent processes such as DNA polymerization, ATP-dependent-DNA supercoiling, and chromosome fragmentation.
Packaging
1g, 10g
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
K L Goa et al.
Drugs, 53(4), 700-725 (1997-04-01)
Sparfloxacin is a fluoroquinolone antibacterial agent with activity against a broad range of Gram-negative and Gram-positive organisms including Streptococcus pneumoniae, one of the main pathogens in community-acquired pneumonia. In this infection, sparfloxacin has shown efficacy similar to that of amoxicillin
N Rastogi et al.
Antimicrobial agents and chemotherapy, 35(12), 2473-2480 (1991-12-01)
The MICs and MBCs of the new difluorinated quinolone drug sparfloxacin against type strains belonging to 21 species of mycobacteria were screened. The MICs and MBCs were within the range of 0.1 to 2.0 and 0.1 to 4.0 micrograms/ml, respectively
Chengxin Zhi et al.
Journal of medicinal chemistry, 49(4), 1455-1465 (2006-02-17)
Novel Gram-positive (Gram+) antibacterial compounds consisting of a DNA polymerase IIIC (pol IIIC) inhibitor covalently connected to a topoisomerase/gyrase inhibitor are described. Specifically, 3-substituted 6-(3-ethyl-4-methylanilino)uracils (EMAUs) in which the 3-substituent is a fluoroquinolone moiety (FQ) connected by various linkers were
Kenichiro Shimizu et al.
Antimicrobial agents and chemotherapy, 52(10), 3823-3825 (2008-07-23)
A new chromosome-carried quinolone resistance gene from Stenotrophomonas maltophilia, Smqnr, was characterized. The gene was present in type strain CCUG 5866 and was also detected in 24 clinical isolates and showed some allelic diversity. The expression of Smqnr in Escherichia
Radha K Shandil et al.
Antimicrobial agents and chemotherapy, 51(2), 576-582 (2006-12-06)
Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens, and we sought to determine the best in vitro and pharmacodynamic predictors of in vivo efficacy in mice. MICs for Mycobacterium tuberculosis H37Rv were 0.1
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