form
powder
quality
low sulfate content
mol wt
Mw 3000-6000
composition
Sulfur Content, 8-13%
loss
≤10% loss on drying
solubility
H2O: 0.1 g/mL, clear, colorless to slightly yellow
storage temp.
room temp
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General description
Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.
Application
Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.
Biochem/physiol Actions
Dextran sulfate is used for the concentration of viral particles during DNA precipitation and was shown to have a marginal inhibitory effect on Micrococcus luteus and E. coli DNA polymerases.
Preparation Note
Sigma dextrans are derived from Leuconostoc mesenteroides.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Dextran Sulfate as a Contaminant of DNA Extracted from Concentrated Viruses and as an Inhibitor of DNA polymerases.
HITZEMAN, R.
Journal of Virology, 255-257 (1978)
Aaron H Rose et al.
Inflammatory bowel diseases, 21(9), 2005-2015 (2015-06-16)
An important role has emerged for calpain enzymes in regulating inflammation with one isoform, calpain-2, particularly important for macrophage activation. The goal of this study was to determine the therapeutic potential of a synthetic calpain-2 inhibitor, zLLY-CH2F, for colitis and
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