2′-（4-甲基伞形酮）-α;-（4-甲基伞形酮）-α- D - N -乙酰神经氨酸钠盐水合物

Name: 2′-（4-甲基伞形酮）-α;-（4-甲基伞形酮）-α-<SC> D </SC>-<I> N </I>-乙酰神经氨酸 钠盐 水合物
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥96.5% (HPLC)

别名:

4-MUNANA, 4-甲基伞形酮辛酸酯-N-乙酰基-α-D-神经氨酸钠盐水合物, 4-甲基伞形酮基- N -乙酰基-α- D -神经氨酸钠盐水合物

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经验公式（希尔记法）:

C₂₁H₂₄NNaO₁₁ · xH₂O

化学文摘社编号:

76204-02-9

分子量:

489.41 (anhydrous basis)

MDL number:

MFCD00057309

UNSPSC Code:

12352106

NACRES:

NA.32

主要文件

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产品名称

2′-（4-甲基伞形酮）-α;-（4-甲基伞形酮）-α- D - N -乙酰神经氨酸钠盐水合物, BioReagent, suitable for fluorescence, ≥96.5% (HPLC)

SMILES string

O.[H]C(O)(CO)[C@]([H])(O)[C@@H]1OC(C[C@H](O)[C@H]1NC(C)=O)(Oc2ccc3C(C)=CC(=O)Oc3c2)C(=O)O[Na]

InChI

1S/C21H25NO11.Na.H2O/c1-9-5-16(27)31-15-6-11(3-4-12(9)15)32-21(20(29)30)7-13(25)17(22-10(2)24)19(33-21)18(28)14(26)8-23;;/h3-6,13-14,17-19,23,25-26,28H,7-8H2,1-2H3,(H,22,24)(H,29,30);;1H2/q;+1;/p-1/t13-,14?,17+,18?,19+,21+;;/m0../s1

InChI key

NSQMRVBWXQQIKF-NVRWCLOTSA-M

product line

BioReagent

assay

≥96.5% (HPLC)

form

powder

mol wt

489.41 g/mol (anhydrous basis)

composition

free 4-methylumbelliferone, ≤0.5%
water, ≤10%

impurities

≤0.5% free 4-methylumbelliferone
≤10% water

color

white to faint yellow

solubility

H₂O: 50 mg/mL, clear, very slightly yellow

fluorescence

λ_ex 315 nm; λ_em 374 nm (pH.7.0)
λ_ex 365 nm; λ_em 445 nm (after cleavage by neuraminidase)

suitability

suitable for fluorescence

storage temp.

−20°C

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Application

2′-(4-甲基伞形酮辛酸酯)-α-D-N-乙酰神经氨酸或 4-MUNANA 用作底物，以开发基于微孔板的神经氨酸酶抑制剂检测。荧光底物2ʹ-(4-甲基伞形酮辛酸酯)-α-D-N-乙酰神经氨酸（4-MUNANA）用于研究阿司匹林和塞来昔布靶向哺乳动物神经氨酸酶-1 的分子机制。

Biochem/physiol Actions

神经氨酸酶荧光测定法的底物。用于 PAGE 中唾液酸酶的荧光染色。

General description

2′-(4-甲基伞形酮辛酸酯)-α-D-N-乙酰神经氨酸或 4-MUNANA 是一种合成荧光底物，模仿天然存在的神经氨酸酶底物。酶-底物水解产生4-甲基伞形酮（4-MU），通过荧光法测定。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

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Synthesis of novel N-acetylneuraminic acid derivatives as substrates for rapid detection of influenza virus neuraminidase.

Wei Yang et al.

Carbohydrate research, 359, 92-96 (2012-08-29)

Two novel N-acetylneuraminic acid derivatives, luciferyl N-acetylneuraminic acid (1) and luciferyl 4,7-di-O-methyl-N-acetylneuraminic acid (2), were designed and synthesized as substrates for the rapid detection of influenza virus neuraminidase. The sensitivity and specificity of the assays with compound 1 or 2

The quenching effect of flavonoids on 4-methylumbelliferone, a potential pitfall in fluorimetric neuraminidase inhibition assays.

Jarinrat Kongkamnerd et al.

Journal of biomolecular screening, 16(7), 755-764 (2011-06-04)

Many assays aimed to test the inhibitory effects of synthetic molecules, and naturally occurring products on the neuraminidase activity exploit the hydrolysis of 2'-O-(4-methylumbelliferyl)-N-acetylneuraminic acid (4-MUNANA). The amount of the released product, 4-methylumbelliferone (4-MU), is then measured fluorimetrically. The authors

A microplate-based screening assay for neuraminidase inhibitors.

A F Li et al.

Drug discoveries & therapeutics, 3(6), 260-265 (2009-12-01)

Neuraminidase (NA) represents a highly promising new target for drug development in influenza virus genes. Rapid screening of enzyme inhibitors is a key method for the identification of leading compounds. In order to speed up the screening for enzyme inhibitors

Role of Sialic Acid in Brachyspira hyodysenteriae Adhesion to Pig Colonic Mucins.

Macarena P Quintana-Hayashi et al.

Infection and immunity, 87(7) (2019-04-17)

Infection with Brachyspira hyodysenteriae results in mucoid hemorrhagic diarrhea. This pathogen is associated with the colonic mucus layer, mainly composed of mucins. Infection regulates mucin O-glycosylation in the colon and increases mucin secretion as well as B. hyodysenteriae binding sites

Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells.

Bessi Qorri et al.

Drug design, development and therapy, 14, 4149-4167 (2020-10-30)

Aspirin (acetylsalicylic acid) and celecoxib have been used as potential anti-cancer therapies. Aspirin exerts its therapeutic effect in both cyclooxygenase (COX)-dependent and -independent pathways to reduce tumor growth and disable tumorigenesis. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduces factors that

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2′-（4-甲基伞形酮）-α;-（4-甲基伞形酮）-α- D - N -乙酰神经氨酸钠盐水合物

BioReagent, suitable for fluorescence, ≥96.5% (HPLC)

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关于此项目

主要文件

属性

产品名称

SMILES string

InChI

InChI key

product line

assay

form

mol wt

composition

impurities

color

solubility

fluorescence

suitability

storage temp.

相关类别

说明

Application

Biochem/physiol Actions

General description

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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2′-（4-甲基伞形酮）-α;-（4-甲基伞形酮）-α- D - N -乙酰神经氨酸 钠盐 水合物

BioReagent, suitable for fluorescence, ≥96.5% (HPLC)

选择尺寸

关于此项目

主要文件

属性

产品名称

SMILES string

InChI

InChI key

product line

assay

form

mol wt

composition

impurities

color

solubility

fluorescence

suitability

storage temp.

相关类别

说明

Application

Biochem/physiol Actions

General description

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

已有该产品？

同行评审论文

技术文章和实验方案

商品

技术服务

2′-（4-甲基伞形酮）-α;-（4-甲基伞形酮）-α- D - N -乙酰神经氨酸钠盐水合物