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2′-（4-甲基伞形酮）-α;-（4-甲基伞形酮）-α- D - N -乙酰神经氨酸 钠盐 水合物

BioReagent, suitable for fluorescence, ≥96.5% (HPLC)

别名:

4-MUNANA, 4-甲基伞形酮辛酸酯-N-乙酰基-α-D-神经氨酸钠盐水合物, 4-甲基伞形酮基- N -乙酰基-α- D -神经氨酸 钠盐 水合物

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关于此项目

经验公式（希尔记法）:
C21H24NNaO11 · xH2O
化学文摘社编号:
76204-02-9
分子量:
489.41 (anhydrous basis)
MDL number:
MFCD00057309
UNSPSC Code:
12352106
NACRES:
NA.32
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product line

BioReagent

assay

≥96.5% (HPLC)

form

powder

mol wt

489.41 g/mol (anhydrous basis)

composition

free 4-methylumbelliferone, ≤0.5% , water, ≤10%

impurities

≤0.5% free 4-methylumbelliferone, ≤10% water

color

white to faint yellow

solubility

H2O: 50 mg/mL, clear, very slightly yellow

fluorescence

λex 315 nm; λem 374 nm (pH.7.0), λex 365 nm; λem 445 nm (after cleavage by neuraminidase)

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

O.[H]C(O)(CO)[C@]([H])(O)[C@@H]1OC(C[C@H](O)[C@H]1NC(C)=O)(Oc2ccc3C(C)=CC(=O)Oc3c2)C(=O)O[Na]

InChI

1S/C21H25NO11.Na.H2O/c1-9-5-16(27)31-15-6-11(3-4-12(9)15)32-21(20(29)30)7-13(25)17(22-10(2)24)19(33-21)18(28)14(26)8-23;;/h3-6,13-14,17-19,23,25-26,28H,7-8H2,1-2H3,(H,22,24)(H,29,30);;1H2/q;+1;/p-1/t13-,14?,17+,18?,19+,21+;;/m0../s1

InChI key

NSQMRVBWXQQIKF-NVRWCLOTSA-M

General description

2′-(4-甲基伞形酮辛酸酯)-α-D-N-乙酰神经氨酸或 4-MUNANA 是一种合成荧光底物，模仿天然存在的神经氨酸酶底物。 酶-底物水解产生4-甲基伞形酮（4-MU），通过荧光法测定。

Application

2′-(4-甲基伞形酮辛酸酯)-α-D-N-乙酰神经氨酸或 4-MUNANA 用作底物，以开发基于微孔板的神经氨酸酶抑制剂检测。 荧光底物2ʹ-(4-甲基伞形酮辛酸酯)-α-D-N-乙酰神经氨酸（4-MUNANA）用于研究阿司匹林和塞来昔布靶向哺乳动物神经氨酸酶-1 的分子机制。

Biochem/physiol Actions

神经氨酸酶荧光测定法的底物。用于 PAGE 中唾液酸酶的荧光染色。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN2157
BCCM2083
BCCL1143
BCCJ4786
BCCG9959

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商品

Sialic Acid

Understand sialic acid structure, function, signaling, and modifications. Easily find products for sialic acid research.

Wei Yang et al.
Carbohydrate research, 359, 92-96 (2012-08-29)
Two novel N-acetylneuraminic acid derivatives, luciferyl N-acetylneuraminic acid (1) and luciferyl 4,7-di-O-methyl-N-acetylneuraminic acid (2), were designed and synthesized as substrates for the rapid detection of influenza virus neuraminidase. The sensitivity and specificity of the assays with compound 1 or 2
A F Li et al.
Drug discoveries & therapeutics, 3(6), 260-265 (2009-12-01)
Neuraminidase (NA) represents a highly promising new target for drug development in influenza virus genes. Rapid screening of enzyme inhibitors is a key method for the identification of leading compounds. In order to speed up the screening for enzyme inhibitors
Jarinrat Kongkamnerd et al.
Journal of biomolecular screening, 16(7), 755-764 (2011-06-04)
Many assays aimed to test the inhibitory effects of synthetic molecules, and naturally occurring products on the neuraminidase activity exploit the hydrolysis of 2'-O-(4-methylumbelliferyl)-N-acetylneuraminic acid (4-MUNANA). The amount of the released product, 4-methylumbelliferone (4-MU), is then measured fluorimetrically. The authors
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货号GTIN
H0501-100G04061832722535
H0501-25G04061832722559
H0501-10G04061833663233
69587-25MG04061833278031
69587-5MG04061832532967